Is Thiourea ⚠️ safe in cosmetics?
Thiourea ⚠️ has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited. 2 toxicological study endpoint(s) are available in our database.
Thiourea ⚠️
Also known as: Caswell No. 855, EINECS 200-543-5, EPA Pesticide Chemical Code 080201, RCRA waste number U219, Sulourea (+13 more)
INCI: THIOUREA
Thiourea ⚠️ (CAS 62-56-6) is a cosmetic cosmetic ingredient functioning as Historically: Depilatory, Reducing Agent — NOW PROHIBITED. Reported NOAEL =6.88 mg/kg bw/day in Rat (INCHEM_WHO_cicads_cicads_cicad49); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 62-56-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Thiourea ⚠️ is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H351, H361, H361d, H411, H317, H320, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Historically: Depilatory, Reducing Agent — NOW PROHIBITED
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
thiourea
InChIKey
UMGDCJDMYOKAJW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not specifically banned by FDA, but classified as suspected carcinogen; subject to adulteration provisions if unsafe
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Thiourea ⚠️.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Thiourea ⚠️. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =6.88 mg/kg bw/day | oral | Rat | Chronic toxicity | INCHEM_WHO_cicads_cicads_cicad49 |
| NOAEL | =25 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the thyroid. This substance is possibly carcinogenic to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
Sup 7, 79
Evaluation Year
2000
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Health HazardHarmful / IrritantEnvironmental Hazard
Hazard Class and Category
Carc. 2; Repr. 2; Acute Tox. 4 *; Aquatic Chronic 2
Hazard Statements
- H351 Suspected of causing cancer
- H361d ***
- H302 Harmful if swallowed
- H411 Toxic to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 321
(EC) 2009/1223
CMR: Carcinogenic Cat. 2(),Reprotoxic Cat. 2()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics |
| CA | banned | - | - |
| ASEAN | banned | - | All cosmetic products prohibited |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (5)
Carcinogen Classification
3, not classifiable as to its carcinogenicity to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Thiourea | Group 3: Not classifiable as to its carcinogenicity to humans | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 79: (2001) Some Thyrotropic Agents
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated thiourea for carcinogenicity. According to their analysis, the weight-of-evidence for thiourea is group B2, which is based on sufficient evidence in animals. No data available in humans. As a group B2 chemical, thiourea is considered a probable human carcinogen.. | Evaluation: There is inadequate
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0680
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
... Skin irritant ...
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Humectant
Regulatory List Membership (4)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Thiourea ⚠️.
Regulatory Flags
potential-allergen
prop65
eu_banned_cosmetics
fda_food_additive
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Thiourea ⚠️ by CAS number or substance name.
Studies
2
Lowest NOAEL
6.88 mg/kg bw/day
Highest NOAEL
25 mg/kg bw/day
ToxValDB_ECHA_IUCLID
INCHEM_WHO_cicads_cicads_cicad49
Known Synonyms
Caswell No. 855
EINECS 200-543-5
EPA Pesticide Chemical Code 080201
RCRA waste number U219
Sulourea
beta-Thiopseudourea
2-Thiopseudourea
Thiuronium
USAF EK-497
Thiomocovina
UNII-GYV9AM2QAG
2-thiourea
Thiocarbamid
Thiokarbamid
aminothioamide
aminothiocarboxamide
carbonothioic diamide
thiocarbonic acid diamide
Chemical Function
Humectant
Biocide
Regulatory Lists
Cons electronics mech appliances and machinery; Europe
active_ingredient; Europe; Pesticides
active_ingredient; Europe; Pesticides
OEHHA Proposition 65 (3/2019)
fracking; water
OEHHA Proposition 65 (1/2023)
banned; Europe; Personal care
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
THIOUREA
ChEMBL ID
CHEMBL260876
Frequently Asked Questions
Is Thiourea ⚠️ allowed in the EU?
Thiourea ⚠️ EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiourea ⚠️ do in cosmetics?
Thiourea ⚠️ functions as: Historically: Depilatory, Reducing Agent — NOW PROHIBITED. It is classified as a cosmetic ingredient in our database. CAS number: 62-56-6.
What is the NOAEL for Thiourea ⚠️?
The NOAEL (No Observed Adverse Effect Level) for Thiourea ⚠️ is =6.88 mg/kg bw/day based on a Chronic toxicity study via oral route in Rat. A total of 2 study endpoints are available. Source: INCHEM_WHO_cicads_cicads_cicad49.
Is Thiourea ⚠️ used outside cosmetics?
Thiourea ⚠️ also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Thiourea ⚠️ have different safety status in cosmetics vs industrial chemicals?
Thiourea ⚠️ is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H351, H361, H361d, H411, H317, H320, H335).
Compliance Tools
Check Thiourea ⚠️ compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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