NOAEL Studies
Cosmetic Ingredient
Thiourea ⚠️ NOAEL Studies
INCI: THIOUREA
CAS: 62-56-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
California Proposition 65 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | SQE10 | ug/day | - | - | 1988-01-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQE10 | ug/day | - | - | 1988-01-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQE10 | ug/day | - | - | 1988-01-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQE10 | ug/day | - | - | 1988-01-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1988-01-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1988-01-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1988-01-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1988-01-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"10","source_table":"prop65_listings"} |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 2000 | IARC Monographs | {"additional_info":"volume_publication_year=2001","evaluation_year":2000,"source_table":"iarc_classifications","volume":"Sup 7, 79"} |
INCHEM_WHO_cicads_cicads_cicad49 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_cicads_cicads_cicad49 | LOAEL | =27.5 | mg/kg bw/day | Rat | oral | 2-year | Chronic toxicity | document_id=cicads_cicads_cicad49; title=Thiourea (CICADS 49, 2003); path=mirror/documents/cicads/cicads/cicad49.htm; row_hash=779c734fa6b32ca3; raw_unit=mg/kg body weight per day; context=A LOAEL of 27.5 mg/kg body weight per day (reduction of body weight and enlargement of thyroid gland) and a NOAEL of 6.88 mg/kg body weight per day for rats were given for a 2-year drinking-water study (Hartzell, 1942, 1945). |
| INCHEM_WHO_cicads_cicads_cicad49 | NOAEL | =6.88 | mg/kg bw/day | Rat | oral | 2-year | Chronic toxicity | document_id=cicads_cicads_cicad49; title=Thiourea (CICADS 49, 2003); path=mirror/documents/cicads/cicads/cicad49.htm; row_hash=17914e7e88ae1450; raw_unit=mg/kg body weight per day; context=A LOAEL of 27.5 mg/kg body weight per day (reduction of body weight and enlargement of thyroid gland) and a NOAEL of 6.88 mg/kg body weight per day for rats were given for a 2-year drinking-water study (Hartzell, 1942, 1945). |
NTP_ICE_acute_inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >0.195 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5026; Record_ID=acute_inhalation_1345; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9021348; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.195; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/3/3/?documentUUID=aecace3b-375b-4518-a3cf-9ba3b00955d0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021348; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021348 |
| NTP_ICE_acute_inhalation | LC50 | >=0.17 | mg/L | - | Inhalation | Duration=ca. 4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5027; Record_ID=acute_inhalation_1039; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9021348; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>=; Response=0.17; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/3/3/?documentUUID=2adeaf78-99a6-4a82-a818-de11b4409b51; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021348; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021348 |
NTP_ICE_cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=9915; Record_ID=cancer_2859; Data_Type=WOE; Formulation_Name=Thiourea; Mixture=Chemical; DTXSID=DTXSID9021348; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/97; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021348; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021348 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15498; RecordID=ARPathway2016_1413; DatasetName=ARPathway2016; DTXSID=DTXSID9021348; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021348; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021348 |
ToxValDB_ECHA_IUCLID 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =3 | mg/kg bw/day | Rat | injection | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61bf1e4b096bca877004d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/3/5?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15815096:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5eb12ec75d2152c7a3ab2c2b4972dd21 |
| ToxValDB_ECHA_IUCLID | LEL | =557.5 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b40a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/8?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15820480:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e3656b8fb56cfbd13e1627d1b6e0e24e |
| ToxValDB_ECHA_IUCLID | LEL | =131 | mg/kg bw/day | Rat | oral | short-term; 10 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb77e4b0a7c65d22645e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844751_15844752:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c5a3f97421a9b0c679bf45529bf692c |
| ToxValDB_ECHA_IUCLID | LEL | =25 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9bf1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15849649:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ca7c98dd9b77d1d5408dffaa3f69ecdc |
| ToxValDB_ECHA_IUCLID | LOAEC | =2000 | ppm | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1ece4b0a7c65d230cfc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/9/3?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15821828:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb09510aca3a1e6f92a4c7060c6713e3 |
| ToxValDB_ECHA_IUCLID | LOAEL | =50 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b40aa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/8?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819476_15820481:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_186ecceca6c95c43bf03e872a4363291 |
| ToxValDB_ECHA_IUCLID | LOAEL | ~55 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb77e4b0a7c65d226422; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832274_15849651:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_657ead3c6e4138e4666661d2b871e965 |
| ToxValDB_ECHA_IUCLID | LOAEL | ~59 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb77e4b0a7c65d226422; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832275_15849650:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a6b721a4bce48fd31bdf89308e77a2a6 |
| ToxValDB_ECHA_IUCLID | LOAEL | <300 | mg/kg bw/day | Rat | oral | - | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb77e4b0a7c65d22642e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=haematology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|organ weight; STUDY_GROUP=ECHA IUCLID:15832358:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b8ccf21298edc3743f1e64138d6a414d |
| ToxValDB_ECHA_IUCLID | LOAEL | =30 | mg/kg bw/day | Rat | oral | subchronic; 8 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9bfd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food efficiency; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECHA IUCLID:15847759:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8b7c942fd866b3abe8c55f2eea17e283 |
| ToxValDB_ECHA_IUCLID | LOAEL | ~21 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb77e4b0a7c65d22643d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832275_15849650:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2512124dac882f2cbc2a322f4ee7a23c |
| ToxValDB_ECHA_IUCLID | LOAEL | ~20 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb77e4b0a7c65d22643d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832274_15849651:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2505bfe06eae350f6cbd4ef149f830fe |
| ToxValDB_ECHA_IUCLID | LOEL | ~70 | mg/kg bw/day | Rat | oral | short-term; 10 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb77e4b0a7c65d226441; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15844690:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ad227f56f2f3cf0b6a22becd65c5a35 |
| ToxValDB_ECHA_IUCLID | NOAEL | =25 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b40aa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/8?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819476_15820481:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cce8edb855950150933262f45989db55 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=27.5 | mg/kg bw/day | Rat | oral | chronic; 53 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9bef; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15847465:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ec4bcd4f21d52089c27fd2ddfb46d8f4 |
| ToxValDB_ECHA_IUCLID | NOEL | =12 | mg/kg bw/day | Rat | oral | short-term; 10 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb77e4b0a7c65d22645e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844751_15844752:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_804459252a2813fec85aeef3f7a6aa7d |
| ToxValDB_ECHA_IUCLID | NOEL | >=1.73 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9be1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15849646:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e2bf31f922f6c429fe9d28f579399013 |
| ToxValDB_ECHA_IUCLID | NOEL | >=2.65 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9be1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11868/7/6/2?documentUUID=f3b36df7-fd40-469e-9aa4-485816fd292d; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15849647:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_981b2dc264d23f791dd4cdf234c8b186 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =5 | mg/kg bw/day | Rat | injection | short-term; 7 days | short-term | LONG_REF=Biochem. Pharmacol.24(21): 2003-2005 Idris,R., and K. Ahmad The Effect of Allylisothiocyanate and Other Antithyroid Compounds on Blood Coagulation in Rats 1975; TITLE=The Effect of Allylisothiocyanate and Other Antithyroid Compounds on Blood Coagulation in Rats; AUTHOR=Idris,R., and K. Ahmad; DOI=10.1016/0006-2952(75)90393-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=82885; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1975; ORIGINAL_YEAR=1975; TOXICOLOGICAL_EFFECT=Biochemistry: Phosphatidyl choline (phospholipid) content|Biochemistry: Phosphatidyl ethanolamine (phospholipid) content|Biochemistry: Sphingomyelin|Biochemistry: Total phospholipid content|Physiology: Clotting time; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|other; STUDY_GROUP=ECOTOX:15601813:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8eaca6cee340a07cdadaa59d5a3e1fc6 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635242:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f3a54e89f37de3dec8b37d05ef6ea297 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | GYV9AM2QAG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH4N2S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GYV9AM2QAG"} |
| openFDA substances | FDA UNII substance identifier | GYV9AM2QAG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH4N2S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GYV9AM2QAG"} |
| openFDA substances | FDA UNII substance identifier | GYV9AM2QAG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH4N2S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GYV9AM2QAG"} |
| openFDA substances | FDA UNII substance identifier | GYV9AM2QAG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH4N2S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GYV9AM2QAG"} |