Moderate Cosmetic Ingredient GHS Classified

ANILINE

Also known as: Benzenamine, C.I. Oxidation Base 1, Aniline oil, Arylamine, Benzene, amino (+15 more)

ANILINE (CAS 62-53-3) is a cosmetic cosmetic ingredient functioning as Not Reported. NOAEL 23.3 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max II/22 CMR2; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 62-53-3 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

ANILINE is classified GHS Danger (H301, H311, H331, H317, H318, H330, H341, H351) in the chemicals database but is restricted in EU cosmetics at max II/22 CMR2.

Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

62-53-3

View industrial chemical safety profile →

Function

Not Reported

Safety Rating

MODERATE

Chemistry & Identifiers

Formula

C6H7N

93.13 g/mol

EC Number

200-539-3

PubChem CID

6115

IUPAC Name

aniline

InChIKey

PAYRUJLWNCNPSJ-UHFFFAOYSA-N

ChEBI: CHEBI:17296 UNII: SIR7XX2F1K Wikidata: Q186414

Regulatory Status

EU EU Status restricted

EU Max Conc. II/22 CMR2

US US Status Not specifically regulated

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for ANILINE.

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

SkullToxicCancerHealth hazEnviroAqua

Hazard Statements

Toxic if swallowed, in contact with skin or if inhaled Causes damage to red blood cells Causes damage to the blood through prolonged or repeated exposure Causes serious eye irritation May cause an allergic skin reaction Very toxic to aquatic life

Short-term Exposure Effects

The substance is severely irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. See Notes. Exposure could cause haemolysis. This may result in haemolytic anaemia. The effects may be delayed. Medical observation is indicated.

Long-term Exposure Effects

Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in haemolytic anaemia.

Routes of Exposure

The substance can be absorbed into the body by inhalation, through the skin also as a vapour and by ingestion.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for ANILINE across SCCS product categories, with measured dermal absorption where available.

IARC Carcinogenicity

International Agency for Research on Cancer (WHO) monograph evaluation.

IARC Group

Volume

27, Sup 7, 127

Evaluation Year

2020

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word

Danger

Pictograms

Health HazardAcute ToxicityCorrosiveEnvironmental Hazard

Hazard Class and Category

Carc. 2; Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 1; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1

Hazard Statements

H351 Suspected of causing cancer
H341 Suspected of causing genetic defects
H331 Toxic if inhaled
H311 Toxic in contact with skin
H301 Toxic if swallowed
H372 **
H318 Causes serious eye damage
H317 May cause an allergic skin reaction
H400 Very toxic to aquatic life

Specific Concentration Limits / M-factors

*; STOT RE 1; H372: C ≥ 1.0%; STOT RE 2; H373: 0.2% ≤ C < 1.0%

Inserted via ATP: CLP00

Sensitization AOP Dashboard

Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.

DPRA Cys %

DPRA Lys %

2.4%

KeratinoSens IC50

2000 µM

hCLAT CV75

666.6 µg/mL

LLNA EC3

50%

NESIL

12414 µg/cm²

LLNA: Weak (1B) GHS: 1B Human: positive

Source: LLNA: Griem et al. (2003) | Schneider & Akkan (2004); DPRA: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Jaworska 2011 [DOI:10.1002/jat.2869]; KS: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Natsch et al. 2013 [DOI:10.1002/jat.2868]; hCLAT: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]; HPPT: [27] Kligman AM (1966): https://doi.org/10.1038/jid.1966.160

HRIPT Human Patch Test Studies

2 human repeat insult patch tests aggregated from dermatological literature.

Test Type	N	Sensitized	Dose µg/cm²	NESIL µg/cm²	Potency
HMT	-	0	12413.79	-	-
OECD_DA_Human	-	0	-	-	1B (Weak sensitizer)

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

100,000 - 1,000,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Hazard classification: Restricted (Annex XVII)

EU CosIng Annex Listing

European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.

Annex II — Prohibited

Ref: 22

(EC) 2009/1223

CMR: Carcinogenic Cat. 2(),Mutagenic Cat. 2()

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

SA Saudi SFDA (II - Prohibited)

BRIN Brazil/India Cosmetics

Brazil: Prohibited

India: Prohibited (GNRAS)

Additional Jurisdictional Restrictions (5)

Jurisdiction	Status	Max %	Product Type
CN	banned	-	-
IN	banned	-	all cosmetics
CA	banned	-	-
ASEAN	banned	-	All cosmetic products prohibited
KR	prohibited	-	-

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (6)

Carcinogen Classification

3, not classifiable as to its carcinogenicity to humans. (L135)

Source: Toxin and Toxin Target Database (T3DB)

Carcinogen Classification

Aniline | Group 2A: Probably carcinogenic to humans | Volume 27: (1982) Some Aromatic Amines, Anthraquinones and Nitroso Compounds, and Inorganic Fluorides Used in Drinking-water and Dental Preparations | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 127: (2021) Some Aromatic Amines

Source: International Agency for Research on Cancer (IARC)

Evidence for Carcinogenicity

Classification of carcinogenicity: Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. | CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Induction of tumors of the spleen and the body cavity in two strains of rat, and some supporting toxicological evidence. HUMAN CARCINOGENICITY DATA: Inad

Source: Hazardous Substances Data Bank (HSDB)

Endocrine Disruptors

Potential endocrine disrupting compound

Source: NORMAN Suspect List Exchange

ICSC Safety Card

0011

Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Intermediate No specific technical function

Regulatory List Membership (4)

California Proposition 65 (OEHHA) EU Banned in Cosmetics FDA Indirect Food Contact Additives EU CosIng Cosmetics Ingredient Database

Expert Verdict

Expert safety assessment and concern-level summary for ANILINE.

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment prop65 eu_banned_cosmetics eu_cosing_listed

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to ANILINE by CAS number or substance name.

Studies

Lowest NOAEL

23.3 mg/kg bw/day

Highest NOAEL

23.3 mg/kg bw/day

ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip

Known Synonyms

Benzenamine C.I. Oxidation Base 1 Aniline oil Arylamine Benzene, amino Caswell No. 051C CI Oxidation Base 1 EINECS 200-539-3 EPA Pesticide Chemical Code 251400 NCI-C03736 RCRA waste number U012 Huile d'aniline UNII-SIR7XX2F1K Anilin Aniline hydrobromide Aniline reagent Anyvim Benzidam Cyanol D'Aniline

Chemical Function

Intermediate No specific technical function

Regulatory Lists

Indirect additives food contact (10/2018) OEHHA Proposition 65 (3/2019) detected; Europe; Other indirect contact consumer goods detected; emissions; Europe; Other indirect contact consumer goods; water detected; Europe; Toys and children's products Europe; nondetect; Road vehicles air; detected; emissions; Europe; Toys and children's products Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe Mutation Research/Reviews in Genetic Toxicology children; WA Children's Safe Product Act (4/2020) Canada; pharmaceutical children Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound

ANILINE

ChEMBL ID

CHEMBL538

View full pharmaceutical profile →

Frequently Asked Questions

Is ANILINE safe in cosmetics?

ANILINE has a safety rating of "MODERATE" in our database. EU status: restricted.

Is ANILINE allowed in the EU?

ANILINE EU regulatory status: restricted. Maximum allowed concentration: II/22 CMR2. This is based on EU Regulation 1223/2009 and its amendments.

What does ANILINE do in cosmetics?

ANILINE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 62-53-3.

Is ANILINE classified as hazardous under GHS?

ANILINE carries a GHS signal word of "DANGER". Hazard statements: Toxic if swallowed, in contact with skin or if inhaled Causes damage to red blood cells Causes damage to the blood through prolonged or repeated exposure Causes serious eye irritation May cause an allergic skin reaction Very toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Is ANILINE used outside cosmetics?

ANILINE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does ANILINE have different safety status in cosmetics vs industrial chemicals?

ANILINE is classified GHS Danger (H301, H311, H331, H317, H318, H330, H341, H351) in the chemicals database but is restricted in EU cosmetics at max II/22 CMR2.

Compliance Tools

Check ANILINE compliance across multiple jurisdictions:

Ingredient Decoder

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82 Allergen Checker

Check for EU declarable fragrance allergens

Substance Compliance

Check compliance across multiple jurisdictions

MoS Calculator

Calculate Margin of Safety using SCCS methodology

Heavy Metal Limits

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