Also known as: 4-Methyl-2-(2-methylpropyl)tetrahydro-2H-pyran-4-ol, 2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)-, A mixture of: cis-Tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-Tetrahydro-2-isobutyl-4-methylpyran-4-ol, 2-(Isobutyl)-4-hydroxy-4-methyl tetrahydropyran, Florol
INCI: TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL
Tetrahydro-methyl-methylpropyl)-pyran-4-ol (Osyrol) (CAS 63500-71-0) is a cosmetic cosmetic ingredient functioning as Fragrance – floral, muguet/lily-of-the-valley. Reported NOAEL =10 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 63500-71-0 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydro-methyl-methylpropyl)-pyran-4-ol (Osyrol).
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3 study endpoints found for Tetrahydro-methyl-methylpropyl)-pyran-4-ol (Osyrol). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =125 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | dermal | Rat | developmental | ToxValDB_ECHA_IUCLID |
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 4408 | - | - |
| HRIPT | - | 0 | - | - | - |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Expert safety assessment and concern-level summary for Tetrahydro-methyl-methylpropyl)-pyran-4-ol (Osyrol).
Public NOAEL study rows linked to Tetrahydro-methyl-methylpropyl)-pyran-4-ol (Osyrol) by CAS number or substance name.
Tetrahydro-methyl-methylpropyl)-pyran-4-ol (Osyrol) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Tetrahydro-methyl-methylpropyl)-pyran-4-ol (Osyrol) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Tetrahydro-methyl-methylpropyl)-pyran-4-ol (Osyrol) functions as: Fragrance – floral, muguet/lily-of-the-valley. It is classified as a cosmetic ingredient in our database. CAS number: 63500-71-0.
The NOAEL (No Observed Adverse Effect Level) for Tetrahydro-methyl-methylpropyl)-pyran-4-ol (Osyrol) is =10 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Tetrahydro-methyl-methylpropyl)-pyran-4-ol (Osyrol) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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