Is TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL safe in cosmetics?
TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL
Also known as: 4-Methyl-2-(2-methylpropyl)tetrahydro-2H-pyran-4-ol, 2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)-, A mixture of: cis-Tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-Tetrahydro-2-isobutyl-4-methylpyran-4-ol, 2-(Isobutyl)-4-hydroxy-4-methyl tetrahydropyran, Florol
TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL (CAS 63500-71-0) is a cosmetic cosmetic ingredient functioning as Perfuming. Reported NOAEL =10 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 63500-71-0 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-methyl-2-(2-methylpropyl)oxan-4-ol
InChIKey
YVSNOTITPICPTB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =125 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | dermal | Rat | developmental | ToxValDB_ECHA_IUCLID |
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 4408 | - | - |
| HRIPT | - | 0 | - | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
epa_safer_alternative
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL by CAS number or substance name.
Studies
3
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
4-Methyl-2-(2-methylpropyl)tetrahydro-2H-pyran-4-ol
2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)-
A mixture of: cis-Tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-Tetrahydro-2-isobutyl-4-methylpyran-4-ol
2-(Isobutyl)-4-hydroxy-4-methyl tetrahydropyran
Florol
Chemical Function
Fragrance
Deodorizer
Regulatory Lists
IFRA Transparency
consumer_product
SCIL (9/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL allowed in the EU?
TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL do in cosmetics?
TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 63500-71-0.
What is the NOAEL for TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL?
The NOAEL (No Observed Adverse Effect Level) for TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL is =10 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL used outside cosmetics?
TETRAHYDRO-METHYL-METHYLPROPYL)-PYRAN-4-OL also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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