Is Isobutyl Methyl Tetrahydropyranol safe in cosmetics?
Isobutyl Methyl Tetrahydropyranol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Isobutyl Methyl Tetrahydropyranol
Also known as: 4-Methyl-2-(2-methylpropyl)tetrahydro-2H-pyran-4-ol, 2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)-, A mixture of: cis-Tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-Tetrahydro-2-isobutyl-4-methylpyran-4-ol, 2-(Isobutyl)-4-hydroxy-4-methyl tetrahydropyran, Florol
Isobutyl Methyl Tetrahydropyranol (CAS 63500-71-0) is a cosmetic cosmetic ingredient functioning as Deodorizer; Fragrance. Reported NOAEL =10 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 63500-71-0 →
Auto-generated CPSR Part A draft with source citations
Function
Deodorizer; Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-methyl-2-(2-methylpropyl)oxan-4-ol
InChIKey
YVSNOTITPICPTB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isobutyl Methyl Tetrahydropyranol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Isobutyl Methyl Tetrahydropyranol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =125 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | dermal | Rat | developmental | ToxValDB_ECHA_IUCLID |
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 4408 | - | - |
| HRIPT | - | 0 | - | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isobutyl Methyl Tetrahydropyranol.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Isobutyl Methyl Tetrahydropyranol by CAS number or substance name.
Studies
3
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
4-Methyl-2-(2-methylpropyl)tetrahydro-2H-pyran-4-ol
2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)-
A mixture of: cis-Tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-Tetrahydro-2-isobutyl-4-methylpyran-4-ol
2-(Isobutyl)-4-hydroxy-4-methyl tetrahydropyran
Florol
Chemical Function
Fragrance
Deodorizer
Regulatory Lists
IFRA Transparency
consumer_product
SCIL (9/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Isobutyl Methyl Tetrahydropyranol allowed in the EU?
Isobutyl Methyl Tetrahydropyranol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutyl Methyl Tetrahydropyranol do in cosmetics?
Isobutyl Methyl Tetrahydropyranol functions as: Deodorizer; Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 63500-71-0.
What is the NOAEL for Isobutyl Methyl Tetrahydropyranol?
The NOAEL (No Observed Adverse Effect Level) for Isobutyl Methyl Tetrahydropyranol is =10 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Isobutyl Methyl Tetrahydropyranol used outside cosmetics?
Isobutyl Methyl Tetrahydropyranol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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