Is Sodium Acetate safe in cosmetics?
Sodium Acetate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Sodium Acetate
Also known as: Caswell No. 741A, EINECS 204-823-8, EPA Pesticide Chemical Code 044006, FEMA No. 3024, FEMA Number 3024 (+8 more)
INCI: SODIUM ACETATE
Sodium Acetate (CAS 127-09-3) is a cosmetic cosmetic ingredient functioning as Insufficient data. NOAEL 16.6667 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 127-09-3 →
Auto-generated CPSR Part A draft with source citations
Function
Insufficient data
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
sodium acetate
InChIKey
VMHLLURERBWHNL-UHFFFAOYSA-M
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
CIR Expert Panel concluded that sodium acetate - reviewed as part of the methyl acetate and alkyl acetates group - is safe in the present practices of use and concentration in cosmetics.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Sodium Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 21 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 102 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | =50 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Hazard Statements
Causes eye irritation
Short-term Exposure Effects
The substance is mildly irritating to the eyes and skin.
Routes of Exposure
The substance can be absorbed into the body by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sodium Acetate across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
7 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LOAEL | >50 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | >=3600 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| NOAEL | =50 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| LC50 | >7.5 mg/L | Rat | inhalation | - | ChemIDplus |
| LD50 | =6891 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | >10000 mg/kg | Rabbit | dermal | - | ChemIDplus |
| LD50 | =3530 mg/kg | Rat | oral | - | ChemIDplus |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0565
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Evaluation
SODIUM ACETATE | 1973 | NOT LIMITED | Group ADI of "not limited" for acetic acid and its potassium and sodium salts. This ADI was maintained at the forty-ninth meeting (1997). | NMRS 53/TRS 539-JECFA 17/35 | FAS 5/NMRS 53A-JECFA 17/31
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Biocide
Degradant/impurity
Deodorizer
Flame retardant
Flavouring and nutrient
Fragrance
Pharmaceutical
Pigment
Processing aids not otherwise specified
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Acetate.
Regulatory Flags
EU Restricted
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Acetate by CAS number or substance name.
Studies
12
Lowest NOAEL
21 mg/kg bw/day
Highest NOAEL
768.35 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Caswell No. 741A
EINECS 204-823-8
EPA Pesticide Chemical Code 044006
FEMA No. 3024
FEMA Number 3024
Natrium aceticum
NSC 77459
Sodii acetas
Sodium ethanoate
Octan sodny
UNII-NVG71ZZ7P0
Natriumazetat
sodium acetate anhydrous
Chemical Function
pH regulating agent
Deodorizer
Degradant/impurity
Fragrance
Flame retardant
Pigment
Anti-static agent
Flavouring and nutrient
Regulatory Lists
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
animal_products
Europe; plastic_additive
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Canada; pharmaceutical
Canada; pharmaceutical
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe
fracking; water
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SODIUM ACETATE
ChEMBL ID
CHEMBL1354
Max Phase
4
Adverse Event Associations
14
Frequently Asked Questions
Is Sodium Acetate allowed in the EU?
Sodium Acetate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Acetate do in cosmetics?
Sodium Acetate functions as: Insufficient data. It is classified as a cosmetic ingredient in our database. CAS number: 127-09-3.
What is the NOAEL for Sodium Acetate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Acetate is 21 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Is Sodium Acetate classified as hazardous under GHS?
Sodium Acetate carries a GHS signal word of "WARNING". Hazard statements: Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Sodium Acetate used outside cosmetics?
Sodium Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Acetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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