Is Salicylamide safe in cosmetics?
Salicylamide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted. 1 toxicological study endpoint(s) are available in our database.
Salicylamide
Also known as: 2-Hydroxybenzamide (Salicylamide) (o-Hydroxybenzamide), 4-10-00-00169, Andasol, Benzamide, o-hydroxy-, Benzoic acid, 2-hydroxy-, amide (+10 more)
INCI: SALICYLAMIDE
Salicylamide (CAS 65-45-2) is a cosmetic cosmetic ingredient functioning as Antimicrobial / Preservative agent in cosmetics; also pharmaceutical. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 65-45-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Salicylamide is classified GHS Danger (H302, H312, H315, H319, H335, H361, H370, H372) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial / Preservative agent in cosmetics; also pharmaceutical analgesic/antipyretic
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-hydroxybenzamide
InChIKey
SKZKKFZAGNVIMN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Classified as OTC drug active ingredient (analgesic); cosmetic use as preservative/antimicrobial not specifically restricted but lacks FDA monograph for cosmetic claims
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Salicylamide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Salicylamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =500 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Salicylamide across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Pharmaceutical
Expert Verdict
Expert safety assessment and concern-level summary for Salicylamide.
Regulatory Flags
preservative
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Salicylamide by CAS number or substance name.
Studies
4
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
2-Hydroxybenzamide (Salicylamide) (o-Hydroxybenzamide)
4-10-00-00169
Andasol
Benzamide, o-hydroxy-
Benzoic acid, 2-hydroxy-, amide
BRN 0742439
Dolomide
Eggosalil
EINECS 200-609-3
Flarpirina
Amid kyseliny salicylove
Salicilamide
Salicylamidum
UNII-EM8BM710ZC
OHB
Chemical Function
Pharmaceutical
Regulatory Lists
CEDI
pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SALICYLAMIDE
ChEMBL ID
CHEMBL27577
Max Phase
2
Adverse Event Associations
166
Frequently Asked Questions
Is Salicylamide allowed in the EU?
Salicylamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Salicylamide do in cosmetics?
Salicylamide functions as: Antimicrobial / Preservative agent in cosmetics; also pharmaceutical analgesic/antipyretic. It is classified as a cosmetic ingredient in our database. CAS number: 65-45-2.
What is the NOAEL for Salicylamide?
The NOAEL (No Observed Adverse Effect Level) for Salicylamide is =500 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Salicylamide used outside cosmetics?
Salicylamide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Salicylamide have different safety status in cosmetics vs industrial chemicals?
Salicylamide is classified GHS Danger (H302, H312, H315, H319, H335, H361, H370, H372) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Salicylamide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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