What is the NOAEL for Salicylamide?
Salicylamide has 17 NOAEL studies in the database. The lowest reported value is EM8BM710ZC UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Salicylamide
Also known as: 2-Hydroxybenzamide (Salicylamide) (o-Hydroxybenzamide), 4-10-00-00169, Andasol, Benzamide, o-hydroxy-, Benzoic acid, 2-hydroxy-, amide (+10 more)
CAS 65-45-2
Salicylamide (CAS 65-45-2) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Salicylamide is classified GHS Danger (H302, H312, H315, H319, H335, H361, H370, H372) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Salicylamide
CAS Number
65-45-2
DTXSID
DTXSID3021726
Molecular Formula
C7H7NO2
InChI Key
SKZKKFZAGNVIMN-UHFFFAOYSA-N
Monoisotopic Mass
137.047678
Synonyms
2-Hydroxybenzamide (Salicylamide) (o-Hydroxybenzamide)4-10-00-00169AndasolBenzamide, o-hydroxy-Benzoic acid, 2-hydroxy-, amideBRN 0742439DolomideEggosalilEINECS 200-609-3FlarpirinaAmid kyseliny salicyloveSalicilamide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Pharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| EM8BM710ZC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EM8BM710ZC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EM8BM710ZC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EM8BM710ZC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =980 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1020 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1100 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >1600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =71 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =82 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =87 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =142 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =600 | mg/kg bw/day | LEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2 | mmol/kg | NOEL | injection | Mouse | ToxValDB_ECOTOX |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Salicylamide | 200-609-3 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SALICYLAMIDE
ChEMBL Phase
2
Adverse Events
166
Bioactivity
3
Frequently Asked Questions
What regulatory lists include Salicylamide?
Salicylamide appears on 3 regulatory/inventory lists including CEDI, pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Salicylamide used in cosmetics?
Yes, Salicylamide is also indexed as a cosmetic ingredient under the name Salicylamide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Salicylamide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Salicylamide have different safety status in cosmetics vs industrial chemicals?
Salicylamide is classified GHS Danger (H302, H312, H315, H319, H335, H361, H370, H372) in the chemicals database but is allowed in EU cosmetics.
Is Salicylamide used outside industrial chemicals?
Salicylamide also appears in cosmetics, pharmaceutical databases.