Is Polyepsilon-Lysine safe in cosmetics?
Polyepsilon-Lysine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Polyepsilon-Lysine
INCI: POLYEPSILON-LYSINE
Polyepsilon-Lysine (CAS 28211-04-3) is a cosmetic cosmetic ingredient functioning as Preservative (antimicrobial); hair conditioning; skin conditioning; surfactant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 28211-04-3 →
Auto-generated CPSR Part A draft with source citations
Function
Preservative (antimicrobial); hair conditioning; skin conditioning; surfactant (emulsifying)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2S)-2-amino-N-methylheptanamide
InChIKey
YLBHPLDJISPYOJ-ZETCQYMHSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA GRAS for food use; permitted in cosmetics without specific restriction. Health Canada lists it as approved (non-medicinal).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Polyepsilon-Lysine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Polyepsilon-Lysine.
Regulatory Flags
preservative
Chemical Function
Softener and conditioner
Frequently Asked Questions
Is Polyepsilon-Lysine allowed in the EU?
Polyepsilon-Lysine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polyepsilon-Lysine do in cosmetics?
Polyepsilon-Lysine functions as: Preservative (antimicrobial); hair conditioning; skin conditioning; surfactant (emulsifying). It is classified as a cosmetic ingredient in our database. CAS number: 28211-04-3.
Compliance Tools
Check Polyepsilon-Lysine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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