NOAEL Studies
Cosmetic Ingredient
Salicylamide NOAEL Studies
INCI: SALICYLAMIDE
CAS: 65-45-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=e6981558-5581-4535-9992-85453ce03e11.i6z; document=9d6eda37-6ffc-4986-a5de-176a267955e2_e6981558-5581-4535-9992-85453ce03e11.i6d; document_key=9d6eda37-6ffc-4986-a5de-176a267955e2/e6981558-5581-4535-9992-85453ce03e11; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1946; basis=other:; key_result=false; entry_uuid=805987be-03fa-4296-8fc1-1b7788068331 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=e6981558-5581-4535-9992-85453ce03e11.i6z; document=9d6eda37-6ffc-4986-a5de-176a267955e2_e6981558-5581-4535-9992-85453ce03e11.i6d; document_key=9d6eda37-6ffc-4986-a5de-176a267955e2/e6981558-5581-4535-9992-85453ce03e11; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1946; basis=other:; key_result=false; entry_uuid=805987be-03fa-4296-8fc1-1b7788068331 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=e6981558-5581-4535-9992-85453ce03e11.i6z; document=9d6eda37-6ffc-4986-a5de-176a267955e2_e6981558-5581-4535-9992-85453ce03e11.i6d; document_key=9d6eda37-6ffc-4986-a5de-176a267955e2/e6981558-5581-4535-9992-85453ce03e11; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1946; basis=other:; key_result=false; entry_uuid=805987be-03fa-4296-8fc1-1b7788068331 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | >=250 | mg/kg bw/day | mouse | oral: drinking water | - | sub-chronic toxicity: oral | dossier=e6981558-5581-4535-9992-85453ce03e11.i6z; document=fa77fae6-0bfb-49cf-b82f-46a20d0cf344_e6981558-5581-4535-9992-85453ce03e11.i6d; document_key=fa77fae6-0bfb-49cf-b82f-46a20d0cf344/e6981558-5581-4535-9992-85453ce03e11; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1952; basis=other:; key_result=false; entry_uuid=ec118928-a7fb-4ed9-9836-488bc78114ea |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | >=250 | mg/kg bw/day | mouse | oral: drinking water | - | sub-chronic toxicity: oral | dossier=e6981558-5581-4535-9992-85453ce03e11.i6z; document=fa77fae6-0bfb-49cf-b82f-46a20d0cf344_e6981558-5581-4535-9992-85453ce03e11.i6d; document_key=fa77fae6-0bfb-49cf-b82f-46a20d0cf344/e6981558-5581-4535-9992-85453ce03e11; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1952; basis=other:; key_result=false; entry_uuid=ec118928-a7fb-4ed9-9836-488bc78114ea |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | >=250 | mg/kg bw/day | mouse | oral: drinking water | - | sub-chronic toxicity: oral | dossier=e6981558-5581-4535-9992-85453ce03e11.i6z; document=fa77fae6-0bfb-49cf-b82f-46a20d0cf344_e6981558-5581-4535-9992-85453ce03e11.i6d; document_key=fa77fae6-0bfb-49cf-b82f-46a20d0cf344/e6981558-5581-4535-9992-85453ce03e11; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1952; basis=other:; key_result=false; entry_uuid=ec118928-a7fb-4ed9-9836-488bc78114ea |
NTP_ICE_acute_oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | <2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_8996; row=5535; data_type=In Vivo; mixture=Chemical; chemical_name=Salicylamide; preferred_name=Salicylamide; dtxsid=DTXSID3021726; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021726; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3021726; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1020 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_8993; row=5536; data_type=In Vivo; mixture=Chemical; chemical_name=Salicylamide; preferred_name=Salicylamide; dtxsid=DTXSID3021726; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021726; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3021726; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1100 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_8994; row=5537; data_type=In Vivo; mixture=Chemical; chemical_name=Salicylamide; preferred_name=Salicylamide; dtxsid=DTXSID3021726; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021726; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3021726; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >1600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_8995; row=5538; data_type=In Vivo; mixture=Chemical; chemical_name=Salicylamide; preferred_name=Salicylamide; dtxsid=DTXSID3021726; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021726; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3021726; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =980 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_8992; row=5539; data_type=In Vivo; mixture=Chemical; chemical_name=Salicylamide; preferred_name=Salicylamide; dtxsid=DTXSID3021726; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021726; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3021726; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=14172; RecordID=ARPathway2016_1451; DatasetName=ARPathway2016; DTXSID=DTXSID3021726; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021726 |
ToxValDB_ECHA_IUCLID 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =71 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2210/7/3/2?documentUUID=e6981558-5581-4535-9992-85453ce03e11; YEAR=1955; ORIGINAL_YEAR=1955; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15801054_15801055:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_01aee2d439167e9bb5333ab7bbdd5605 |
| ToxValDB_ECHA_IUCLID | LEL | =82 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2210/7/3/2?documentUUID=e6981558-5581-4535-9992-85453ce03e11; YEAR=1955; ORIGINAL_YEAR=1955; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15801054_15801055:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_81bfb506711d2f8437430d4e97789ae5 |
| ToxValDB_ECHA_IUCLID | LEL | =87 | mg/kg bw/day | Mouse | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2210/7/3/2?documentUUID=e6981558-5581-4535-9992-85453ce03e11; YEAR=1955; ORIGINAL_YEAR=1955; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15807527_15807528:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f2163406e807c29ad2f041714c402f05 |
| ToxValDB_ECHA_IUCLID | LEL | =142 | mg/kg bw/day | Mouse | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2210/7/3/2?documentUUID=e6981558-5581-4535-9992-85453ce03e11; YEAR=1955; ORIGINAL_YEAR=1955; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15807527_15807528:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_642512f26f36b2bfd763e1e254200e95 |
| ToxValDB_ECHA_IUCLID | LEL | =600 | mg/kg bw/day | Rat | injection | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c55e4b096bca87718b4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2210/7/3/5?documentUUID=e6981558-5581-4535-9992-85453ce03e11; YEAR=1955; ORIGINAL_YEAR=1955; STUDY_GROUP=ECHA IUCLID:15815356:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0156c3ff296ce3196988a28af5aa3994 |
| ToxValDB_ECHA_IUCLID | NOAEL | =500 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be5b2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2210?documentUUID=b83d4a36-12a0-4b15-afd1-97385c489fe2; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15823175:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_03a19ee9c6c4b58a691b061a550ef887 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =2 | mmol/kg | Mouse | injection | short-term; 1.25 days | short-term | LONG_REF=Mutat. Res.66:33-43 King,M.T., H. Beikirch, K. Eckhardt, E. Gocke, and D. Wild Mutagenicity Studies with X-Ray Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial, Drosophila and Mammalian Test Systems 1979; TITLE=Mutagenicity Studies with X-Ray Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial, Drosophila and Mammalian Test Systems; AUTHOR=King,M.T., H. Beikirch, K. Eckhardt, E. Gocke, and D. Wild; DOI=10.1016/0165-1218(79)90005-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=181059; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Genetics: Micronuclei; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15604334:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6db3d35a7712593d53307f235d8baaa5 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | EM8BM710ZC | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H7NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EM8BM710ZC"} |
| openFDA substances | FDA UNII substance identifier | EM8BM710ZC | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H7NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EM8BM710ZC"} |
| openFDA substances | FDA UNII substance identifier | EM8BM710ZC | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H7NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EM8BM710ZC"} |
| openFDA substances | FDA UNII substance identifier | EM8BM710ZC | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H7NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EM8BM710ZC"} |