Is Regulatory and safe in cosmetics?
Regulatory and has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Regulatory and
Also known as: EINECS 249-277-1, L-5-Oxoproline monosodium salt, 5-Oxo-L-proline monosodium salt, UNII-1V74VH163T
INCI: REGULATORY AND
Regulatory and (CAS 28874-51-3) is a cosmetic cosmetic ingredient functioning as Insufficient Data. Reported NOAEL =7200 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 28874-51-3 →
Auto-generated CPSR Part A draft with source citations
Function
Insufficient Data
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
for cosmetic use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Regulatory and.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Regulatory and. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =7200 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =8200 mg/kg bw/day | oral | Rat | subchronic | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Humectant
Softener and conditioner
Regulatory List Membership (1)
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Regulatory and.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Regulatory and by CAS number or substance name.
Studies
2
Lowest NOAEL
7200 mg/kg bw/day
Highest NOAEL
8200 mg/kg bw/day
ECHA
Known Synonyms
EINECS 249-277-1
L-5-Oxoproline monosodium salt
5-Oxo-L-proline monosodium salt
UNII-1V74VH163T
Chemical Function
Humectant
Anti-static agent
Softener and conditioner
Regulatory Lists
Europe; Personal care
Europe; Personal care
Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Regulatory and allowed in the EU?
Regulatory and EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Regulatory and do in cosmetics?
Regulatory and functions as: Insufficient Data. It is classified as a cosmetic ingredient in our database. CAS number: 28874-51-3.
What is the NOAEL for Regulatory and?
The NOAEL (No Observed Adverse Effect Level) for Regulatory and is =7200 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ECHA.
Is Regulatory and used outside cosmetics?
Regulatory and also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Regulatory and compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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