Is OXACYCLOHEPTADEC-10-EN-2-ONE safe in cosmetics?
OXACYCLOHEPTADEC-10-EN-2-ONE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
OXACYCLOHEPTADEC-10-EN-2-ONE
Also known as: 9-Hexadecenoic acid, 16-hydroxy-, ο-lactone, Δ9-Isoambrettolic acid, lactone, EINECS 249-120-7, FEMA No. 2555, 9-Hexadecenoic acid, 16-hydroxy-, o-lactone (+3 more)
OXACYCLOHEPTADEC-10-EN-2-ONE (CAS 28645-51-4) is a cosmetic cosmetic ingredient functioning as Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 28645-51-4 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(10Z)-1-oxacycloheptadec-10-en-2-one
InChIKey
QILMAYXCYBTEDM-IWQZZHSRSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 310 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for OXACYCLOHEPTADEC-10-EN-2-ONE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to OXACYCLOHEPTADEC-10-EN-2-ONE by CAS number or substance name.
Studies
3
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
9-Hexadecenoic acid, 16-hydroxy-, ο-lactone
Δ9-Isoambrettolic acid, lactone
EINECS 249-120-7
FEMA No. 2555
9-Hexadecenoic acid, 16-hydroxy-, o-lactone
NSC 31697
UNII-0DI2GU512F
Isoambrettolide
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ISOAMBRETTOLIDE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is OXACYCLOHEPTADEC-10-EN-2-ONE allowed in the EU?
OXACYCLOHEPTADEC-10-EN-2-ONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OXACYCLOHEPTADEC-10-EN-2-ONE do in cosmetics?
OXACYCLOHEPTADEC-10-EN-2-ONE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 28645-51-4.
Is OXACYCLOHEPTADEC-10-EN-2-ONE used outside cosmetics?
OXACYCLOHEPTADEC-10-EN-2-ONE also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Similar safety
Antioxidant
OXACYCLOHEXADECENONE
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Fragrance, Perfuming
OXALIC ACID
Moderate
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Chelating
OXALIDE
Good
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Perfuming
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