What is the NOAEL for Oxacycloheptadec-10-en-2-one?
Oxacycloheptadec-10-en-2-one has 8 NOAEL studies in the database. The lowest reported value is 16.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Oxacycloheptadec-10-en-2-one
Also known as: 9-Hexadecenoic acid, 16-hydroxy-, ο-lactone, Δ9-Isoambrettolic acid, lactone, EINECS 249-120-7, FEMA No. 2555, 9-Hexadecenoic acid, 16-hydroxy-, o-lactone (+3 more)
CAS 28645-51-4
Oxacycloheptadec-10-en-2-one (CAS 28645-51-4) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for OXACYCLOHEPTADEC-10-EN-2-ONE →
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Oxacycloheptadec-10-en-2-one
CAS Number
28645-51-4
DTXSID
DTXSID3051965
Molecular Formula
C16H28O2
InChI Key
QILMAYXCYBTEDM-UHFFFAOYSA-N
Monoisotopic Mass
252.20893
Synonyms
9-Hexadecenoic acid, 16-hydroxy-, ο-lactoneΔ9-Isoambrettolic acid, lactoneEINECS 249-120-7FEMA No. 25559-Hexadecenoic acid, 16-hydroxy-, o-lactoneNSC 31697UNII-0DI2GU512FIsoambrettolide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
20 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =16.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0DI2GU512F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0DI2GU512F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0DI2GU512F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0DI2GU512F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 310 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Oxacycloheptadec-10-en-2-one | 249-120-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Oxacycloheptadec-10-en-2-one?
Oxacycloheptadec-10-en-2-one appears on 4 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), IFRA Transparency, and 1 more. Source: EPA CPDat.
Is Oxacycloheptadec-10-en-2-one used in cosmetics?
Yes, Oxacycloheptadec-10-en-2-one is also indexed as a cosmetic ingredient under the name OXACYCLOHEPTADEC-10-EN-2-ONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Oxacycloheptadec-10-en-2-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Oxacycloheptadec-10-en-2-one used outside industrial chemicals?
Oxacycloheptadec-10-en-2-one also appears in cosmetics, food safety, cannabis databases.