NOAEL Studies Cosmetic Ingredient

OXACYCLOHEPTADEC-10-EN-2-ONE NOAEL Studies

CAS: 28645-51-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE skin sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6586; Record_ID=skin_sensitization_invivo_1506; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3051965; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2011; 21820029; 10.1016/j.fct.2011.07.052|McGinty et al. 2011; 21801791; 10.1016/j.fct.2011.07.025; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3051965
NTP ICE skin sensitization Induction dose per skin area 310 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6584; Record_ID=skin_sensitization_invivo_1506; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3051965; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=310; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2011; 21820029; 10.1016/j.fct.2011.07.052|McGinty et al. 2011; 21801791; 10.1016/j.fct.2011.07.025; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3051965
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6590; Record_ID=skin_sensitization_invivo_1506; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3051965; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2011; 21820029; 10.1016/j.fct.2011.07.052|McGinty et al. 2011; 21801791; 10.1016/j.fct.2011.07.025; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3051965
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =16.4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633935:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_449c20f6db4956bbab519eb893f7f726
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 0DI2GU512F UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"0DI2GU512F"}
openFDA substances FDA UNII substance identifier 0DI2GU512F UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"0DI2GU512F"}
openFDA substances FDA UNII substance identifier 0DI2GU512F UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"0DI2GU512F"}
openFDA substances FDA UNII substance identifier 0DI2GU512F UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"0DI2GU512F"}