Is OLEAMIDOPROPYL DIMETHYLAMINE safe in cosmetics?
OLEAMIDOPROPYL DIMETHYLAMINE has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted. 3 toxicological study endpoint(s) are available in our database.
OLEAMIDOPROPYL DIMETHYLAMINE
Also known as: N-(Dimethylaminopropyl)oleamide, 9-Octadecenamide, N-[3-(dimethylamino)propyl]-, (9Z)-, 9-Octadecenamide, N-[3-(dimethylamino)propyl]-, (Z)-, Oleamide, N-[3-(dimethylamino)propyl]-, (9Z)-N-[3-(Dimethylamino)propyl]-9-octadecenamide (+10 more)
OLEAMIDOPROPYL DIMETHYLAMINE (CAS 109-28-4) is a cosmetic cosmetic ingredient functioning as Antistatic. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 109-28-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
OLEAMIDOPROPYL DIMETHYLAMINE is classified GHS Danger (H314, H315, H317, H318, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Antistatic
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(Z)-N-[3-(dimethylamino)propyl]octadec-9-enamide
InChIKey
UCWYGNTYSWIDSW-QXMHVHEDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
CIR: SQ - IJT 38(S1):39-69,2019
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for OLEAMIDOPROPYL DIMETHYLAMINE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =25 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
| NOAEL | =75 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
| NOAEL | =200 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for OLEAMIDOPROPYL DIMETHYLAMINE across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for OLEAMIDOPROPYL DIMETHYLAMINE based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
surfactant
EU Allergen Listed
no
Patch Test Positive Rate
1.0%
Cross-reactivity Group
amidoamine-group
Reaction Type
contact-dermatitis
Source: NACDG; IVDK; ESSCA
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "surfactant", "cross_reactivity_group": "amidoamine-group", "patch_test_frequency_pct": "1.0", "sensitization_rate": "moderate", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "NACDG; IVDK; ESSCA"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for OLEAMIDOPROPYL DIMETHYLAMINE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to OLEAMIDOPROPYL DIMETHYLAMINE by CAS number or substance name.
Studies
3
Lowest NOAEL
25 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
ECHA
Known Synonyms
N-(Dimethylaminopropyl)oleamide
9-Octadecenamide, N-[3-(dimethylamino)propyl]-, (9Z)-
9-Octadecenamide, N-[3-(dimethylamino)propyl]-, (Z)-
Oleamide, N-[3-(dimethylamino)propyl]-
(9Z)-N-[3-(Dimethylamino)propyl]-9-octadecenamide
Lexamine O 13
Oleamidopropyl-3-dimethylamine
Oleamidopropyldimethylamine
Oleic acid 3-(N,N-dimethylamino)propylamide
Ritasil OWE 4660
Schercodine O
Tegamine 0-13
Tegamine O 13
N-[3-(Dimethylamino)propyl]oleamid
N-[3-(dimetilamino)propil]oleamida
Chemical Function
Anti-static agent
Fragrance
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is OLEAMIDOPROPYL DIMETHYLAMINE allowed in the EU?
OLEAMIDOPROPYL DIMETHYLAMINE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OLEAMIDOPROPYL DIMETHYLAMINE do in cosmetics?
OLEAMIDOPROPYL DIMETHYLAMINE functions as: Antistatic. It is classified as a cosmetic ingredient in our database. CAS number: 109-28-4.
What is the NOAEL for OLEAMIDOPROPYL DIMETHYLAMINE?
The NOAEL (No Observed Adverse Effect Level) for OLEAMIDOPROPYL DIMETHYLAMINE is =25 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ECHA.
Is OLEAMIDOPROPYL DIMETHYLAMINE used outside cosmetics?
OLEAMIDOPROPYL DIMETHYLAMINE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does OLEAMIDOPROPYL DIMETHYLAMINE have different safety status in cosmetics vs industrial chemicals?
OLEAMIDOPROPYL DIMETHYLAMINE is classified GHS Danger (H314, H315, H317, H318, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check OLEAMIDOPROPYL DIMETHYLAMINE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Arginine
Excellent
Same category
Amino acid / pH Adjuster
D-Panthenol
Excellent
Same category
Hair and skin conditioning, humectant...
Dicaprylyl Ether
Excellent
Same category
Emollient
Emulsifying Wax
Excellent
Same category
O/W emulsifier; stabilizes oil-in-wat...
Ethyl Butyrate
Excellent
Same category
Perfuming, Masking
Fructose
Excellent
Same category
Humectant, Skin Conditioning, Flavori...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
(ARCTIUM LAPPA/CARROT/COLOCASIA ESCULENTA/DIOSCOREA BATATAS/GARLIC/GINGER/IPOMOEA BATATAS/NELUMBO NUCIFERA/ONION/POTATO BULBS)/(CHESTNUT/CITRUS UNSHIU/EGGPLANT/FIG/GRAPE/KIWI/LYCOPERSICON ESCULENTUM/MALUS PUMILA/MUME/PEACH/PLUM/PUMPKIN/PYRUS SEROTINA/RADISH/ZIZIPHUS JUJUBA FRUIT)/(ALLIUM TUBEROSUM/ALOE BARBADENSIS/ANGELICA UTILIS/BRASSICA OLERACEA ACEPHALA/CABBAGE/CELERY/SACCHARINA JAPONICA/UNDARIA PINNATIFIDA LEAF)/(ALLIUM FISTULOSUM/ENTEROMORPHA COMPRESSA/OENANTHE JAVANICA STALK)/LENTINULA EDODES/SUCROSE FERMENT FILTRATE
Good
Similar safety
Humectant, Skin Conditioning - Humect...
5-Hexen-2-One
Moderate
Chemical family
Flavouring and nutrient; Fragrance
Butyl Butyrate
Good
Chemical family
Solvent, masking agent, fragrance ing...
Butyl Isovalerate
Good
Chemical family
Fragrance
Is OLEAMIDOPROPYL DIMETHYLAMINE in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for OLEAMIDOPROPYL DIMETHYLAMINE in your formulation.