Is OCTAHYDROCOUMARIN safe in cosmetics?
OCTAHYDROCOUMARIN has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
OCTAHYDROCOUMARIN
Also known as: Bicyclononalactone, Cyclohexyl lactone, Cyclohexyllactone, Octahydro-1-benzopyran-2-one, 2H-1-Benzopyran-2-one, octahydro- (+4 more)
OCTAHYDROCOUMARIN (CAS 4430-31-3) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 128 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 4430-31-3 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3,4,4a,5,6,7,8,8a-octahydrochromen-2-one
InChIKey
MSFLYJIWLHSQLG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for OCTAHYDROCOUMARIN. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =128 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =383 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =386 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for OCTAHYDROCOUMARIN across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5400 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (5)
JECFA Number
1166
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BICYCLONONALACTONE | 2023 | No safety concern at current levels of intake when used as a flavouring agent | Considered for specifications only | TRS 1050-JECFA 96/46 | FAS 52-JECFA 61/175
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CYCLOHEXYL LACTONE | 2023 | No safety concern at current levels of intake when used as a flavouring agent | Considered for specifications only | TRS 1050-JECFA 96/46 | FAS 52-JECFA 61/175
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
OCTAHYDROCOUMARIN | 2023 | No safety concern at current levels of intake when used as a flavouring agent | Considered for specifications only | TRS 1050-JECFA 96/46 | FAS 52-JECFA 61/175
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
OCTAHYDRO-2H-1-BENZOPYRAN-2-ONE | 2023 | No safety concern at current levels of intake when used as a flavouring agent | Considered for specifications only | TRS 1050-JECFA 96/46 | FAS 52-JECFA 61/175
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for OCTAHYDROCOUMARIN.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to OCTAHYDROCOUMARIN by CAS number or substance name.
Studies
3
Lowest NOAEL
128 mg/kg bw/day
Highest NOAEL
386 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Bicyclononalactone
Cyclohexyl lactone
Cyclohexyllactone
Octahydro-1-benzopyran-2-one
2H-1-Benzopyran-2-one, octahydro-
Coumarin, octahydro-
EINECS 224-623-4
FEMA No. 3791
UNII-H6VNF31DVW
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is OCTAHYDROCOUMARIN allowed in the EU?
OCTAHYDROCOUMARIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OCTAHYDROCOUMARIN do in cosmetics?
OCTAHYDROCOUMARIN functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 4430-31-3.
What is the NOAEL for OCTAHYDROCOUMARIN?
The NOAEL (No Observed Adverse Effect Level) for OCTAHYDROCOUMARIN is =128 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is OCTAHYDROCOUMARIN used outside cosmetics?
OCTAHYDROCOUMARIN also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check OCTAHYDROCOUMARIN compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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