What is the NOAEL for Octahydro-2H-1-benzopyran-2-one?
Octahydro-2H-1-benzopyran-2-one has 12 NOAEL studies in the database. The lowest reported value is 6.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Octahydro-2H-1-benzopyran-2-one
Also known as: Bicyclononalactone, Cyclohexyl lactone, Cyclohexyllactone, Octahydro-1-benzopyran-2-one, 2H-1-Benzopyran-2-one, octahydro- (+4 more)
CAS 4430-31-3
Octahydro-2H-1-benzopyran-2-one (CAS 4430-31-3) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Octahydro-2H-1-benzopyran-2-one
CAS Number
4430-31-3
DTXSID
DTXSID7052105
Molecular Formula
C9H14O2
InChI Key
MSFLYJIWLHSQLG-UHFFFAOYSA-N
Monoisotopic Mass
154.09938
Synonyms
BicyclononalactoneCyclohexyl lactoneCyclohexyllactoneOctahydro-1-benzopyran-2-one2H-1-Benzopyran-2-one, octahydro-Coumarin, octahydro-EINECS 224-623-4FEMA No. 3791UNII-H6VNF31DVW
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
22 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =6.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| H6VNF31DVW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H6VNF31DVW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H6VNF31DVW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H6VNF31DVW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =3900 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =128 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =383 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =386 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Octahydro-2H-1-benzopyran-2-one | 224-623-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Octahydro-2H-1-benzopyran-2-one?
Octahydro-2H-1-benzopyran-2-one appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Octahydro-2H-1-benzopyran-2-one used in cosmetics?
Yes, Octahydro-2H-1-benzopyran-2-one is also indexed as a cosmetic ingredient under the name OCTAHYDROCOUMARIN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Octahydro-2H-1-benzopyran-2-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Octahydro-2H-1-benzopyran-2-one used outside industrial chemicals?
Octahydro-2H-1-benzopyran-2-one also appears in cosmetics, cannabis databases.