Also known as: Ahcoquinone Blue IR, EINECS 224-618-7, NSC 47721, UNII-G5UX3K0728
INCI: CI 60730
Acid Violet 43 (CAS 4430-18-6) is a cosmetic cosmetic ingredient functioning as Non-oxidative hair dye / colorant (anthraquinone dye). NOAEL 350 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited, max 0.5%; 5 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
US NotesExt. D&C Violet No. 2 — listed for externally applied drugs and cosmetics; certification required
For full compliance data across multiple jurisdictions, use the
Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Violet 43.
Calculate MoS for your specific formulation with the
MoS Calculator.
Toxicological Studies
3 study endpoints found for Acid Violet 43. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=200 mg/kg bw/day
oral
Rat
subchronic
ToxValDB_ECHA_IUCLID
NOAEL
=435 mg/kg bw/day
oral
Rat
reproduction developmental
ToxValDB_ECHA_IUCLID
NOAEL
=940 mg/kg bw/day
oral
Rat
reproduction developmental
ToxValDB_ECHA_IUCLID
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: safe
NOAEL: 200 mg/kg bw/d (not specified)
the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat
cir
Verdict: safe
NOAEL: 1000 mg/kg bw/d (not specified)
the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat
cir
Verdict: safe
NOAEL: 800 mg/kg bw/d (oral)
the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat
cir
Verdict: safe
NOAEL: 200 mg/kg bw/d (oral)
the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat
cir
Verdict: safe
NOAEL: 54.4 % (oral)
the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Acid Violet 43 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Violet
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Ahcoquinone Blue IREINECS 224-618-7NSC 47721UNII-G5UX3K0728
Chemical Function
DyeFragrance
Regulatory Lists
Europe; Personal care - hair coloringEurope; Personal care - hair coloringEurope; Personal care - hair coloringEurope; Personal care - hair coloringIFRA Transparencyinert_ingredient; non_food_use; PesticidesSCIL (9/2019)Europe; Personal care - hair styling and care - shampoo-dandruffPersonal careEurope; Personal care; restrictedSCIL (9/2019)Europe; Personal care
Australian Status
AICIS status:listed
Frequently Asked Questions
Is Acid Violet 43 safe in cosmetics?
Acid Violet 43 has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 3 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Acid Violet 43 allowed in the EU?
Acid Violet 43 EU regulatory status: prohibited. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Violet 43 do in cosmetics?
Acid Violet 43 functions as: Non-oxidative hair dye / colorant (anthraquinone dye). It is classified as a cosmetic ingredient in our database. CAS number: 4430-18-6.
What is the NOAEL for Acid Violet 43?
The NOAEL (No Observed Adverse Effect Level) for Acid Violet 43 is =200 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Acid Violet 43 used outside cosmetics?
Acid Violet 43 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Acid Violet 43 have different safety status in cosmetics vs industrial chemicals?
Acid Violet 43 is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications (H318, H412).
Compliance Tools
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