NOAEL Studies Cosmetic Ingredient

OCTAHYDROCOUMARIN NOAEL Studies

CAS: 4430-31-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3900 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_6525; row=12658; data_type=In Vivo; mixture=Chemical; chemical_name=Octahydro-2H-1-benzopyran-2-one; preferred_name=Octahydro-2H-1-benzopyran-2-one; dtxsid=DTXSID7052105; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7052105; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7260; Record_ID=skin_sensitization_invivo_1659; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7052105; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1978: report to RIFM|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7052105
NTP_ICE_skin_sensitization Induction dose per skin area 5400 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7258; Record_ID=skin_sensitization_invivo_1659; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7052105; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5400; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1978: report to RIFM|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7052105
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7264; Record_ID=skin_sensitization_invivo_1659; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7052105; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1978: report to RIFM|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7052105
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =383 mg/kg bw/day Rat oral - developmental GUIDELINE=other:; QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bda86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21134/7/9/3?documentUUID=5043bb2c-ac95-482d-bf69-766208211d19; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: changes in litter size and weights; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824830:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_17feff8440558deb9eaa6a8aec6a164d
ToxValDB_ECHA_IUCLID NOAEL =128 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=other:; QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bda86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21134/7/9/3?documentUUID=5043bb2c-ac95-482d-bf69-766208211d19; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=maternal: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15824831:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fd855b731a164461c0e54cf289e1c95e
ToxValDB_ECHA_IUCLID NOAEL =386 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaafde4b0a7c65d1b857b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21134/7/9/2?documentUUID=5043bb2c-ac95-482d-bf69-766208211d19; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15862835:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2aeecc34782e8c6c82bc4052bdaabb97
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =6.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633872:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f66cdf04e901cff0a0b9552d4e72d454
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier H6VNF31DVW UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"H6VNF31DVW"}
openFDA substances FDA UNII substance identifier H6VNF31DVW UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"H6VNF31DVW"}
openFDA substances FDA UNII substance identifier H6VNF31DVW UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"H6VNF31DVW"}
openFDA substances FDA UNII substance identifier H6VNF31DVW UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"H6VNF31DVW"}