Is NIACIN safe in cosmetics?
NIACIN has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed. 7 toxicological study endpoint(s) are available in our database.
NIACIN
Also known as: Vitamin B3 (niacin or nicotinic acid), 5-22-02-00057, Acidum nicotinicum, BRN 0109591, Caswell No. 598 (+14 more)
NIACIN (CAS 59-67-6) is a cosmetic cosmetic ingredient functioning as Antistatic, Smoothing. NOAEL 0.14 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 59-67-6 →
Auto-generated CPSR Part A draft with source citations
Function
Antistatic, Smoothing
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
pyridine-3-carboxylic acid
InChIKey
PVNIIMVLHYAWGP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed — GRAS (Generally Recognized As Safe) as a vitamin; no specific cosmetic restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
7 study endpoints found for NIACIN. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 49 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rabbit | Subchronic | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 395 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | =50 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Hazard Statements
Causes eye irritation Harmful to aquatic life
Short-term Exposure Effects
The substance is mildly irritating to the eyes.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for NIACIN across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LC50 | >3800 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| LD50 | =3720 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | =4550 mg/kg | Rabbit | oral | - | ChemIDplus |
| LD50 | =7000 mg/kg | Rat | oral | - | ChemIDplus |
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | =5210 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =4500 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >5000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >5000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =8050 mg/kg | Rat | oral | - | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
stability
{"shelf_life_months": "36", "shelf_life_opened_months": "24", "storage_temp_min_c": "15", "storage_temp_max_c": "30", "light_sensitive": "no", "air_sensitive": "no", "moisture_sensitive": "no", "oxidation_prone": "no", "requires_nitrogen_blanket": "no", "stability_indicator": "stable", "degradation_products": "minimal", "recommended_packaging": "standard packaging", "antioxidant_pairing": "not req…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1702
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Flavouring and nutrient
Humectant
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for NIACIN.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to NIACIN by CAS number or substance name.
Studies
7
Lowest NOAEL
49 mg/kg bw/day
Highest NOAEL
400 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
Vitamin B3 (niacin or nicotinic acid)
5-22-02-00057
Acidum nicotinicum
BRN 0109591
Caswell No. 598
Davitamon PP
Direktan
EINECS 200-441-0
EPA Pesticide Chemical Code 056701
Nicagin
Nicocidin
Nicocrisina
Niconat
Niconazid
Nicosyl
Nicotamin
Nicotene
Nicotil
Nicotine acid
Chemical Function
Anti-static agent
Humectant
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
Europe; supplements
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical
inert_ingredient; non_food_use; Pesticides
pharmaceutical
Europe; supplements
Europe; food_additive; supplements
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NIACIN
ChEMBL ID
CHEMBL573
Max Phase
4
Adverse Event Associations
1170
Frequently Asked Questions
Is NIACIN allowed in the EU?
NIACIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NIACIN do in cosmetics?
NIACIN functions as: Antistatic, Smoothing. It is classified as a cosmetic ingredient in our database. CAS number: 59-67-6.
What is the NOAEL for NIACIN?
The NOAEL (No Observed Adverse Effect Level) for NIACIN is 49 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.
Is NIACIN classified as hazardous under GHS?
NIACIN carries a GHS signal word of "WARNING". Hazard statements: Causes eye irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is NIACIN used outside cosmetics?
NIACIN also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NIACIN compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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