NOAEL Studies Cosmetic Ingredient

NIACIN NOAEL Studies

CAS: 59-67-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 150 mg/kg bw/day rabbit oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2000 mg/kg bw/day dog oral 35 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 300 mg/kg bw/day rat oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 100 mg/kg bw/day rat oral 7 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 400 mg/kg bw/day rat oral 4 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day dog oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 395 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 49 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =11650 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8045; row=2104; data_type=In Vivo; mixture=Chemical; chemical_name=Nicotinic acid; preferred_name=Nicotinic acid; dtxsid=DTXSID1020932; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020932; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =8900 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8043; row=2105; data_type=In Vivo; mixture=Chemical; chemical_name=Nicotinic acid; preferred_name=Nicotinic acid; dtxsid=DTXSID1020932; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020932; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =7000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8041; row=2106; data_type=In Vivo; mixture=Chemical; chemical_name=Nicotinic acid; preferred_name=Nicotinic acid; dtxsid=DTXSID1020932; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020932; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =4500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_8037; row=2107; data_type=In Vivo; mixture=Chemical; chemical_name=Nicotinic acid; preferred_name=Nicotinic acid; dtxsid=DTXSID1020932; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020932; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =5210 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_8039; row=2108; data_type=In Vivo; mixture=Chemical; chemical_name=Nicotinic acid; preferred_name=Nicotinic acid; dtxsid=DTXSID1020932; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020932; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 3.54 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=442; Record_ID=adme_parameters_1138; Data_Type=Measured; DTXSID=DTXSID1020932; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=3.54; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020932
NTP_ICE_adme_parameters Fu 0.594 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=443; Record_ID=adme_parameters_1138; Data_Type=Measured; DTXSID=DTXSID1020932; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.594; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020932
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=12190; RecordID=ARPathway2016_1380; DatasetName=ARPathway2016; DTXSID=DTXSID1020932; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020932
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c9706; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20155/7/6/2?documentUUID=3cb8ad67-a4eb-42a1-b05f-8f9a9303e553; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843787_15844810:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_883693aca49eb318dd89cff6a85d6bb4
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633776:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8fcc9e2a6659771ef7b60d1a5da3ab74
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 2679MF687A UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H5NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2679MF687A"}
openFDA substances FDA UNII substance identifier 2679MF687A UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H5NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2679MF687A"}
openFDA substances FDA UNII substance identifier 2679MF687A UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H5NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2679MF687A"}
openFDA substances FDA UNII substance identifier 2679MF687A UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H5NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2679MF687A"}