Is NAD+ Cosmetic safe in cosmetics?
NAD+ Cosmetic has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
NAD+ Cosmetic
Also known as: 5-26-16-00399, BRN 3584133, EINECS 200-184-4, Nicotinamide dinucleotide, Nicotineamide adenine dinucleotide (+8 more)
INCI: NICOTINAMIDE ADENINE DINUCLEOTIDE
NAD+ Cosmetic (CAS 53-84-9) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted, max 5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 53-84-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
InChIKey
BAWFJGJZGIEFAR-NNYOXOHSSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
5%
US US Status
restricted
US Notes
OTC Drug classification - regulatory status requires further clarification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for NAD+ Cosmetic.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for NAD+ Cosmetic.
Known Synonyms
5-26-16-00399
BRN 3584133
EINECS 200-184-4
Nicotinamide dinucleotide
Nicotineamide adenine dinucleotide
Pyridine, nucleotide diphosphate
beta-Diphosphopyridine nucleotide
beta-NAD
beta-NAD+
beta-Nicotinamide adenine dinucleotide
Nadidum
UNII-0U46U6E8UK
β-Nicotinamide adenine dinucleotide hydrate
Chemical Function
Softener and conditioner
Regulatory Lists
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NADIDE
ChEMBL ID
CHEMBL1234613
Max Phase
2
Adverse Event Associations
39
Frequently Asked Questions
Is NAD+ Cosmetic allowed in the EU?
NAD+ Cosmetic EU regulatory status: permitted. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.
What does NAD+ Cosmetic do in cosmetics?
NAD+ Cosmetic functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 53-84-9.
Is NAD+ Cosmetic used outside cosmetics?
NAD+ Cosmetic also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NAD+ Cosmetic compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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NICOTINAMIDE ADENINE DINUCLEOTIDE
Good
Chemical family
Skin Conditioning
PRASTERONE
Moderate
Chemical family
Skin Conditioning
Prasterone (DHEA)
Poor
Chemical family
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