Is NICOTINAMIDE ADENINE DINUCLEOTIDE safe in cosmetics?
NICOTINAMIDE ADENINE DINUCLEOTIDE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
NICOTINAMIDE ADENINE DINUCLEOTIDE
Also known as: 5-26-16-00399, BRN 3584133, EINECS 200-184-4, Nicotinamide dinucleotide, Nicotineamide adenine dinucleotide (+8 more)
NICOTINAMIDE ADENINE DINUCLEOTIDE (CAS 53-84-9) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 53-84-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
InChIKey
BAWFJGJZGIEFAR-NNYOXOHSSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for NICOTINAMIDE ADENINE DINUCLEOTIDE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
5-26-16-00399
BRN 3584133
EINECS 200-184-4
Nicotinamide dinucleotide
Nicotineamide adenine dinucleotide
Pyridine, nucleotide diphosphate
beta-Diphosphopyridine nucleotide
beta-NAD
beta-NAD+
beta-Nicotinamide adenine dinucleotide
Nadidum
UNII-0U46U6E8UK
β-Nicotinamide adenine dinucleotide hydrate
Chemical Function
Softener and conditioner
Regulatory Lists
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NADIDE
ChEMBL ID
CHEMBL1234613
Max Phase
2
Adverse Event Associations
39
Frequently Asked Questions
Is NICOTINAMIDE ADENINE DINUCLEOTIDE allowed in the EU?
NICOTINAMIDE ADENINE DINUCLEOTIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NICOTINAMIDE ADENINE DINUCLEOTIDE do in cosmetics?
NICOTINAMIDE ADENINE DINUCLEOTIDE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 53-84-9.
Is NICOTINAMIDE ADENINE DINUCLEOTIDE used outside cosmetics?
NICOTINAMIDE ADENINE DINUCLEOTIDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NICOTINAMIDE ADENINE DINUCLEOTIDE compliance across multiple jurisdictions:
Ingredient Decoder
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Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Good
Similar safety
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Moderate
Chemical family
Skin Conditioning
PRASTERONE
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Poor
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Skin conditioning agent (hormonal — d...
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