Is PRASTERONE safe in cosmetics?
PRASTERONE has a safety rating of "MODERATE" in our database. EU status: restricted.
Moderate
Cosmetic Ingredient
PRASTERONE
Also known as: DHEA, 5,6-Didehydroisoandrosterone, 4-08-00-00994, BRN 2058110, Caswell No. 051F (+13 more)
PRASTERONE (CAS 53-43-0) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: restricted, max II/37. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 53-43-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
PRASTERONE is classified GHS Danger (H302, H312, H315, H319, H332, H335, H351, H360) in the chemicals database but is restricted in EU cosmetics at max II/37.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin Conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
InChIKey
FMGSKLZLMKYGDP-USOAJAOKSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
II/37
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Pharmaceutical
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for PRASTERONE.
Regulatory Flags
cosing-sourced
eu-restricted
skin-conditioning
needs-enrichment
Known Synonyms
DHEA
5,6-Didehydroisoandrosterone
4-08-00-00994
BRN 2058110
Caswell No. 051F
5,6-Dehydroisoandrostorone
EINECS 200-175-5
EPA Pesticide Chemical Code 126510
Epiandrosterone, 5-dehydro-
UNII-459AG36T1B
Gynodian
(+)-Dehydroisoandrosterone
(2R,5S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-7-en-14-one
(3-beta)-3-Hydroxyandrost-5-en-17-one
(3beta)-3-hydroxy-Androst-5-en-17-one
(3beta,16alpha)-3,16-dihydroxy-androst-5-en-17-one
3-beta-Hydroxy-5-androsten-17-one
3-beta-Hydroxyandrost-5-en-17-one
Chemical Function
Softener and conditioner
Pharmaceutical
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical; prohibited
pharmaceutical; prohibited
pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PRASTERONE
ChEMBL ID
CHEMBL90593
Max Phase
4
Adverse Event Associations
832
Frequently Asked Questions
Is PRASTERONE allowed in the EU?
PRASTERONE EU regulatory status: restricted. Maximum allowed concentration: II/37. This is based on EU Regulation 1223/2009 and its amendments.
What does PRASTERONE do in cosmetics?
PRASTERONE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 53-43-0.
Is PRASTERONE used outside cosmetics?
PRASTERONE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does PRASTERONE have different safety status in cosmetics vs industrial chemicals?
PRASTERONE is classified GHS Danger (H302, H312, H315, H319, H332, H335, H351, H360) in the chemicals database but is restricted in EU cosmetics at max II/37.
Compliance Tools
Check PRASTERONE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Chemical family
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NICOTINAMIDE ADENINE DINUCLEOTIDE
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