Is METHYLVALERIC ACID safe in cosmetics?
METHYLVALERIC ACID has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
METHYLVALERIC ACID
Also known as: Pentanoic acid, 2-methyl-, Valeric acid, 2-methyl-, 4-02-00-00942, BRN 1720655, EINECS 202-594-9 (+7 more)
METHYLVALERIC ACID (CAS 97-61-0) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 97-61-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
METHYLVALERIC ACID is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
2-methylpentanoic acid
InChIKey
OVBFMEVBMNZIBR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for METHYLVALERIC ACID. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 187.5 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for METHYLVALERIC ACID across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
261
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-METHYLVALERIC ACID | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for METHYLVALERIC ACID.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to METHYLVALERIC ACID by CAS number or substance name.
Studies
1
Lowest NOAEL
187.5 mg/kg bw/day
Highest NOAEL
187.5 mg/kg bw/day
COSMOS_DB
Known Synonyms
Pentanoic acid, 2-methyl-
Valeric acid, 2-methyl-
4-02-00-00942
BRN 1720655
EINECS 202-594-9
FEMA No. 2754
Methylpropylacetic acid
alpha-Methylvaleric acid
NSC 8406
2-Pentanecarboxylic acid
Kyselina 2-methylvalerova
UNII-26A19CG6J9
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1204680
Frequently Asked Questions
Is METHYLVALERIC ACID allowed in the EU?
METHYLVALERIC ACID EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does METHYLVALERIC ACID do in cosmetics?
METHYLVALERIC ACID functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 97-61-0.
What is the NOAEL for METHYLVALERIC ACID?
The NOAEL (No Observed Adverse Effect Level) for METHYLVALERIC ACID is 187.5 mg/kg bw/day based on a Developmental study via oral route in rat. Source: COSMOS_DB.
Is METHYLVALERIC ACID used outside cosmetics?
METHYLVALERIC ACID also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does METHYLVALERIC ACID have different safety status in cosmetics vs industrial chemicals?
METHYLVALERIC ACID is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check METHYLVALERIC ACID compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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