What is the NOAEL for 2-Methylpentanoic acid?
2-Methylpentanoic acid has 25 NOAEL studies in the database. The lowest reported value is 26A19CG6J9 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Methylpentanoic acid
Also known as: Pentanoic acid, 2-methyl-, Valeric acid, 2-methyl-, 4-02-00-00942, BRN 1720655, EINECS 202-594-9 (+7 more)
CAS 97-61-0
2-Methylpentanoic acid (CAS 97-61-0) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2-Methylpentanoic acid is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
25
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
2-Methylpentanoic acid
CAS Number
97-61-0
DTXSID
DTXSID9021633
Molecular Formula
C6H12O2
InChI Key
OVBFMEVBMNZIBR-UHFFFAOYSA-N
Monoisotopic Mass
116.08373
Synonyms
Pentanoic acid, 2-methyl-Valeric acid, 2-methyl-4-02-00-00942BRN 1720655EINECS 202-594-9FEMA No. 2754Methylpropylacetic acidalpha-Methylvaleric acidNSC 84062-Pentanecarboxylic acidKyselina 2-methylvalerovaUNII-26A19CG6J9
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 26A19CG6J9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 26A19CG6J9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 26A19CG6J9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 26A19CG6J9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2040 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =125 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 187.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >219 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >219 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >300 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =340 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =340 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >1000 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1450 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >1450 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >2500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 25 of 25 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methylvaleric acid | 202-594-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1204680
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Methylpentanoic acid?
2-Methylpentanoic acid appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 2-Methylpentanoic acid used in cosmetics?
Yes, 2-Methylpentanoic acid is also indexed as a cosmetic ingredient under the name METHYLVALERIC ACID. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Methylpentanoic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Methylpentanoic acid have different safety status in cosmetics vs industrial chemicals?
2-Methylpentanoic acid is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
Is 2-Methylpentanoic acid used outside industrial chemicals?
2-Methylpentanoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.