Is Methyl Anthranilate safe in cosmetics?
Methyl Anthranilate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Methyl Anthranilate
Also known as: Benzoic acid, 2-amino-, methyl ester, Amino methyl benzoate, o-, BRN 0606965, EINECS 205-132-4, FEMA No. 2682 (+10 more)
INCI: METHYL ANTHRANILATE
Methyl Anthranilate (CAS 134-20-3) is a cosmetic cosmetic ingredient functioning as Fragrance. NOAEL 150 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 134-20-3 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
methyl 2-aminobenzoate
InChIKey
VAMXMNNIEUEQDV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS (FEMA 2682) at flavor concentrations. No specific FDA cosmetic restrictions. Not a sunscreen active (Menthyl Anthranilate/Meradimate is the UV absorber, different compound).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Anthranilate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Methyl Anthranilate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Methyl Anthranilate across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
6480 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [349] Epstein WL (1973): Report to RIFM, 18 December, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6480 | - | - |
| HMT | - | 0 | 6480 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance_ifra
{"cas_number": "134-20-3", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.095", "ifra_max_use_level_category_4_pct": "1.5", "ifra_max_use_level_category_7_pct": "0.22", "ifra_max_use_level_category_11_pct": "0.042", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_p…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A skin irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
1534
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-AMINOBENZOIC ACID METHYL ESTER | 2005 | 0-1.5 mg/kg bw (1979) | The ADI established at the twenty-third meeting was maintained. | TRS 934-JECFA 65/54 | FAS 56-JECFA 65
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
No specific technical function
Solvent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Anthranilate.
Regulatory Flags
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Methyl Anthranilate by CAS number or substance name.
Studies
19
Lowest NOAEL
150 mg/kg bw/day
Highest NOAEL
556 mg/kg bw/day
COSMOS_DB
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Benzoic acid, 2-amino-, methyl ester
Amino methyl benzoate, o-
BRN 0606965
EINECS 205-132-4
FEMA No. 2682
Methylanthranilate
Neroli oil, artifical
Neroli oil, artificial
Nevoli oil
Epa Pesticide Chemical Code 128725
Methylester kyseliny anthranilove
UNII-981I0C1E5W
Anthranilic acid methyl ester
O-methyl anthranilate
o-Carbomethoxyaniline
Chemical Function
Fragrance
Deodorizer
No specific technical function
Flavouring and nutrient
Regulatory Lists
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Europe; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
METHYL ANTHRANILATE
ChEMBL ID
CHEMBL1493986
Frequently Asked Questions
Is Methyl Anthranilate allowed in the EU?
Methyl Anthranilate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Anthranilate do in cosmetics?
Methyl Anthranilate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 134-20-3.
What is the NOAEL for Methyl Anthranilate?
The NOAEL (No Observed Adverse Effect Level) for Methyl Anthranilate is 500 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Is Methyl Anthranilate used outside cosmetics?
Methyl Anthranilate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methyl Anthranilate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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DIETHYL TOLUAMIDE
Good
Chemical family
Skin Protecting
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Menthyl Anthranilate
Moderate
Chemical family
UV Absorber
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