Is Lipase safe in cosmetics?
Lipase has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Lipase
Also known as: Lipase, triacylglycerol, EINECS 232-619-9, GA 56, Rizolipasa, Rizolipasum (+2 more)
INCI: LIPASE
Lipase (CAS 9001-62-1) is a cosmetic cosmetic ingredient functioning as Skin conditioning, cleansing. NOAEL 1248.3 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 9001-62-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Lipase is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning, cleansing
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
sodium 4-(pyridin-2-yldiazenyl)benzene-1,3-diol
InChIKey
KZRPHCQLJZXMJV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No restrictions; enzyme widely used in cosmetics and recognized as safe
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Lipase.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Lipase. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 569 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3535 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 4490 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Lipase across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
5 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "barrier-repair", "mechanism_of_action": "Enzymatic activity, targeted protein modification", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "5-10", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Enzyme r…
baby_pediatric
{"cas_number": "CAS-FUNC-39", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "3", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Functional ingredient - generally safe", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern…
depigmentation
{"cas_number": "9001-62-1", "ingredient_class": "keratinocyte_turnover_enhancer", "primary_mechanism_of_action": "Proteolytic enzyme providing gentle exfoliation and melanin dispersal", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction…
exfoliant
{"cas_number": "9001-62-1", "ingredient_class": "enzymatic_exfoliant", "chemical_subclass": "lipase", "molecular_weight_Da": "~50000", "pH_dependent_activity": "yes", "optimal_pH_range": "7.0-9.0", "penetration_depth": "stratum_corneum", "mechanism_of_action": "lipolysis", "target_bonds": "intercellular_lipids", "onset_of_action": "hours", "comedolytic": "yes", "anti_acne_mechanism": "sebum digest…
stability
{"shelf_life_months": "12", "shelf_life_opened_months": "3", "storage_temp_min_c": "2", "storage_temp_max_c": "8", "light_sensitive": "moderate", "air_sensitive": "no", "moisture_sensitive": "yes", "oxidation_prone": "no", "requires_nitrogen_blanket": "no", "stability_indicator": "unstable", "degradation_products": "denaturation, activity loss", "recommended_packaging": "refrigerate, airless", "an…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Cleaning agent
Flavouring and nutrient
Processing aids not otherwise specified
Softener and conditioner
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Lipase.
Regulatory Flags
epa_safer_alternative
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Lipase by CAS number or substance name.
Studies
5
Lowest NOAEL
569 mg/kg bw/day
Highest NOAEL
4490 mg/kg bw/day
COSMOS_DB
Known Synonyms
Lipase, triacylglycerol
EINECS 232-619-9
GA 56
Rizolipasa
Rizolipasum
UNII-8MYC33932O
Pancrelipase lipase
Chemical Function
Cleaning agent
Chemical reaction regulator
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
pharmaceutical
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
8
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
LIPASE
Food Category
flavoring
Frequently Asked Questions
Is Lipase allowed in the EU?
Lipase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lipase do in cosmetics?
Lipase functions as: Skin conditioning, cleansing. It is classified as a cosmetic ingredient in our database. CAS number: 9001-62-1.
What is the NOAEL for Lipase?
The NOAEL (No Observed Adverse Effect Level) for Lipase is 569 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Is Lipase used outside cosmetics?
Lipase also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Lipase have different safety status in cosmetics vs industrial chemicals?
Lipase is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Lipase compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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