NOAEL Studies Cosmetic Ingredient

Lipase NOAEL Studies

INCI: LIPASE

CAS: 9001-62-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 100 mg/kg bw/day rat oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 569 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2000 mg/kg bw/day rat oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3535 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4490 mg/kg bw/day rat oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 18181 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =20 mL/kg bw Rat oral - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5824/7/3/2?documentUUID=b15a3933-5a79-421d-98a2-8d06fe90f302; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID:15803298:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_697ea3a221e29c14a1205ce67e21c71c
ToxValDB_ECHA_IUCLID LEL >2740 mg/kg bw/day Rat oral - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5824/7/3/2?documentUUID=b15a3933-5a79-421d-98a2-8d06fe90f302; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID:15803299:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4c94e5ddccc406f32f5c20fa452cfe81
ToxValDB_ECHA_IUCLID NOAEL >=1248.3 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf50e4b0a7c65d1cd6d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5824/7/6/2?documentUUID=b15a3933-5a79-421d-98a2-8d06fe90f302; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID:15831717:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_48cac3408adfde7309730facd9ee1e96
ToxValDB_WHO_JECFA_Tox_Studies 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_Tox_Studies NOAEL =669 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afb5ee4b0d99f5a87acce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/6287; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=WHO JECFA Tox Studies:15715910:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_246d7a69cb964a195c7a3f80a1db2912
openFDA substances 16 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8224ZTC4MA UNII - - - protein {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"protein","unii_code":"8224ZTC4MA"}
openFDA substances FDA UNII substance identifier 8224ZTC4MA UNII - - - protein {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"protein","unii_code":"8224ZTC4MA"}
openFDA substances FDA UNII substance identifier 8224ZTC4MA UNII - - - protein {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"protein","unii_code":"8224ZTC4MA"}
openFDA substances FDA UNII substance identifier 8224ZTC4MA UNII - - - protein {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"protein","unii_code":"8224ZTC4MA"}
openFDA substances FDA UNII substance identifier 8MYC33932O UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"8MYC33932O"}
openFDA substances FDA UNII substance identifier 8MYC33932O UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"8MYC33932O"}
openFDA substances FDA UNII substance identifier 8MYC33932O UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"8MYC33932O"}
openFDA substances FDA UNII substance identifier 8MYC33932O UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"8MYC33932O"}
openFDA substances FDA UNII substance identifier OCG8G5QG5K UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"OCG8G5QG5K"}
openFDA substances FDA UNII substance identifier OCG8G5QG5K UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"OCG8G5QG5K"}
openFDA substances FDA UNII substance identifier OCG8G5QG5K UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"OCG8G5QG5K"}
openFDA substances FDA UNII substance identifier OCG8G5QG5K UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"OCG8G5QG5K"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}