Is ISOSORBIDE safe in cosmetics?
ISOSORBIDE has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
ISOSORBIDE
Also known as: 5-19-03-00201, BRN 0080510, Devicoran, D-1,4:3,6-Dianhydroglucitol, 1,4-Dianhydrosorbitol (+14 more)
ISOSORBIDE (CAS 652-67-5) is a cosmetic cosmetic ingredient functioning as Humectant, Skin Conditioning. Reported NOAEL =4800 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 652-67-5 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
InChIKey
KLDXJTOLSGUMSJ-JGWLITMVSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for ISOSORBIDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =4800 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for ISOSORBIDE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
humectant
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to ISOSORBIDE by CAS number or substance name.
Studies
1
Lowest NOAEL
4800 mg/kg bw/day
Highest NOAEL
4800 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
5-19-03-00201
BRN 0080510
Devicoran
D-1,4:3,6-Dianhydroglucitol
1,4-Dianhydrosorbitol
1,4:3,6-Dianhydrosorbitol
1,4:3,6-Dianhydro-D-sorbitol
EINECS 211-492-3
Hydronol
Ismotic
Isobide
(+)-D-Isosorbide
NSC 40725
Vascardin dinitrate
Isosorbida
Isosorbidum
UNII-WXR179L51S
Polysorb PS
Polysorb P
Chemical Function
Humectant
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Frequently Asked Questions
Is ISOSORBIDE allowed in the EU?
ISOSORBIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ISOSORBIDE do in cosmetics?
ISOSORBIDE functions as: Humectant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 652-67-5.
What is the NOAEL for ISOSORBIDE?
The NOAEL (No Observed Adverse Effect Level) for ISOSORBIDE is =4800 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is ISOSORBIDE used outside cosmetics?
ISOSORBIDE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check ISOSORBIDE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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