Is Caffeine Carboxylic Acid safe in cosmetics?
Caffeine Carboxylic Acid has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Caffeine Carboxylic Acid
Also known as: Acephylline, 5-26-14-00088, BRN 0279221, 7-(Carboxymethyl)theophylline, EINECS 211-490-2 (+10 more)
INCI: CAFFEINE CARBOXYLIC ACID
Caffeine Carboxylic Acid (CAS 652-37-9) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 652-37-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Not established — no published NOAEL; supplier data required for calculation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Caffeine Carboxylic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Caffeine Carboxylic Acid.
Known Synonyms
Acephylline
5-26-14-00088
BRN 0279221
7-(Carboxymethyl)theophylline
EINECS 211-490-2
NSC 52996
1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetic acid
Theophyllineacetic acid
Theophylline-7-acetic acid
7-Theophyllinylacetic acid
2-(p-Chlorphenoxy)-2-methylpropyl 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetate
7-Theophyllinessigsaeure
7-Theophyllinylessigsaeure
Acide theophylline-ethanoique-7
UNII-M494UE2YEP
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Frequently Asked Questions
Is Caffeine Carboxylic Acid allowed in the EU?
Caffeine Carboxylic Acid EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Caffeine Carboxylic Acid do in cosmetics?
Caffeine Carboxylic Acid functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 652-37-9.
Is Caffeine Carboxylic Acid used outside cosmetics?
Caffeine Carboxylic Acid also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Caffeine Carboxylic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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