What is the NOAEL for Isosorbide?
Isosorbide has 8 NOAEL studies in the database. The lowest reported value is WXR179L51S UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Isosorbide
Also known as: 5-19-03-00201, BRN 0080510, Devicoran, D-1,4:3,6-Dianhydroglucitol, 1,4-Dianhydrosorbitol (+14 more)
CAS 652-67-5
Isosorbide (CAS 652-67-5) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Isosorbide
CAS Number
652-67-5
DTXSID
DTXSID5046196
Molecular Formula
C6H10O4
InChI Key
KLDXJTOLSGUMSJ-JGWLITMVSA-N
Monoisotopic Mass
146.057909
Synonyms
5-19-03-00201BRN 0080510DevicoranD-1,4:3,6-Dianhydroglucitol1,4-Dianhydrosorbitol1,4:3,6-Dianhydrosorbitol1,4:3,6-Dianhydro-D-sorbitolEINECS 211-492-3HydronolIsmoticIsobide(+)-D-Isosorbide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
HumectantSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| WXR179L51S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WXR179L51S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WXR179L51S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WXR179L51S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =24150 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4800 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1200 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,4:3,6-dianhydro-D-glucitol | 211-492-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Humectants
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ISOSORBIDE
ChEMBL Phase
4
Adverse Events
611
Bioactivity
3
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Isosorbide?
Isosorbide appears on 2 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Isosorbide used in cosmetics?
Yes, Isosorbide is also indexed as a cosmetic ingredient under the name ISOSORBIDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Isosorbide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Isosorbide used outside industrial chemicals?
Isosorbide also appears in cosmetics, pharmaceutical, cannabis databases.