Is Diglycerin safe in cosmetics?
Diglycerin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Diglycerin
Also known as: Diglycerin 801, Diglycerin S, Diglycerol, Great Oil DI 1, K-COL-II (+5 more)
INCI: DIGLYCERIN
Diglycerin (CAS 59113-36-9) is a cosmetic cosmetic ingredient functioning as Humectant. NOAEL 10000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 59113-36-9 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
3-(2,3-dihydroxypropoxy)propane-1,2-diol
InChIKey
GPLRAVKSCUXZTP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR concluded safe as used (2023); up to 28% in rinse-off, up to 5% in leave-on
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diglycerin.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diglycerin across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Diglycerin.
Regulatory Flags
humectant
skin-conditioning
glycerin-derivative
cir-reviewed
no-sccs-opinion
data-gap-absorption
Known Synonyms
Diglycerin 801
Diglycerin S
Diglycerol
Great Oil DI 1
K-COL-II
Resassol DN
oxybispropanediol
Oxybispropandio
oxibispropanodiol
Propanediol, oxybis-
Chemical Function
Humectant
Softener and conditioner
Solvent
Frequently Asked Questions
Is Diglycerin allowed in the EU?
Diglycerin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diglycerin do in cosmetics?
Diglycerin functions as: Humectant. It is classified as a cosmetic ingredient in our database. CAS number: 59113-36-9.
Is Diglycerin used outside cosmetics?
Diglycerin also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diglycerin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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