Is Hydroxylamine HCl safe in cosmetics?
Hydroxylamine HCl has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Hydroxylamine HCl
Also known as: Hydroxylamine, hydrochloride, Hydroxylamine, hydrochloride (1:1), EINECS 226-798-2, Hydroxylamine chloride (1:1), Hydroxylamine-1-hydrochloride (+1 more)
INCI: HYDROXYLAMINE HCL
Hydroxylamine HCl (CAS 5470-11-1) is a cosmetic cosmetic ingredient functioning as Antioxidant / Reducing agent. NOAEL 3.29 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 5470-11-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hydroxylamine HCl is prohibited in EU cosmetics but has active industrial GHS classifications (H290, H302, H312, H315, H317, H319, H351, H373).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Antioxidant / Reducing agent
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
hydroxylamine;hydrochloride
InChIKey
WTDHULULXKLSOZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not specifically prohibited under 21 CFR for cosmetics; no FDA monograph. Permitted by default but flagged by GHS classification.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxylamine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
CorrSkullToxicCancerHealth hazEnviroAqua
Hazard Statements
May be osive to metals Toxic if swallowed Harmful in contact with skin Causes skin and eye irritation May cause an allergic skin reaction Suspected of causing cancer May cause damage to blood May cause damage to blood through prolonged or repeated exposure Very toxic to aquatic life
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Medical observation is indicated.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in the formation of methaemoglobin. Tumours have been detected in experimental animals but may not be relevant to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Hydroxylamine HCl across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0709
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Hydroxylamine HCl.
Regulatory Flags
potential-allergen
Known Synonyms
Hydroxylamine, hydrochloride
Hydroxylamine, hydrochloride (1:1)
EINECS 226-798-2
Hydroxylamine chloride (1:1)
Hydroxylamine-1-hydrochloride
UNII-5X4ZA62Z4Q
Chemical Function
Antioxidant
Regulatory Lists
fracking; water
banned; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HYDROXYLAMMONIUM CHLORIDE
ChEMBL ID
CHEMBL542448
Frequently Asked Questions
Is Hydroxylamine HCl allowed in the EU?
Hydroxylamine HCl EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxylamine HCl do in cosmetics?
Hydroxylamine HCl functions as: Antioxidant / Reducing agent. It is classified as a cosmetic ingredient in our database. CAS number: 5470-11-1.
Is Hydroxylamine HCl classified as hazardous under GHS?
Hydroxylamine HCl carries a GHS signal word of "DANGER". Hazard statements: May be osive to metals Toxic if swallowed Harmful in contact with skin Causes skin and eye irritation May cause an allergic skin reaction Suspected of causing cancer May cause damage to blood May cause damage to blood through prolonged or repeated exposure Very toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Hydroxylamine HCl used outside cosmetics?
Hydroxylamine HCl also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hydroxylamine HCl have different safety status in cosmetics vs industrial chemicals?
Hydroxylamine HCl is prohibited in EU cosmetics but has active industrial GHS classifications (H290, H302, H312, H315, H317, H319, H351, H373).
Compliance Tools
Check Hydroxylamine HCl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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