Is HYDRATROPIC ALDEHYDE safe in cosmetics?
HYDRATROPIC ALDEHYDE has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
HYDRATROPIC ALDEHYDE
Also known as: 2-Phenylpropanal, Benzeneacetaldehyde, .alpha.-methyl-, Benzeneacetaldehyde, alpha-methyl-, Benzeneacetalaldehyde, alpha-methyl-, EINECS 202-255-5 (+14 more)
HYDRATROPIC ALDEHYDE (CAS 93-53-8) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 10 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 93-53-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HYDRATROPIC ALDEHYDE is classified GHS CMR hazard (H315, H317, H319, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
2-phenylpropanal
InChIKey
IQVAERDLDAZARL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for HYDRATROPIC ALDEHYDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | =10 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =25 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for HYDRATROPIC ALDEHYDE across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
58.65%
DPRA Lys %
19.45%
KeratinoSens IC50
181.35 µM
hCLAT CV75
39.35 µg/mL
LLNA EC3
6.3%
NESIL
1296 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: Gerberick et al. (2005); DPRA: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Gerberick et al. 2007 [DOI:10.1093/toxsci/kfm064]; KS: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Joint Research Centre of the European Union 2014; hCLAT: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Nukada et al. 2013 [DOI:10.1016/j.tiv.2012.11.006]; HPPT: [151] Kligman AM (1971): Report to RIFM, 2 April, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1296 | - | - |
| HRIPT | - | 0 | 1550 | - | - |
| OECD_DA_Human | - | 0 | - | - | 1B (Weak sensitizer) |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1467
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-PHENYLPROPIONALDEHYDE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/113 | FAS 54-JECFA 63/525
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CUMENE ALDEHYDE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/113 | FAS 54-JECFA 63/525
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for HYDRATROPIC ALDEHYDE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HYDRATROPIC ALDEHYDE by CAS number or substance name.
Studies
3
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
25 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Phenylpropanal
Benzeneacetaldehyde, .alpha.-methyl-
Benzeneacetaldehyde, alpha-methyl-
Benzeneacetalaldehyde, alpha-methyl-
EINECS 202-255-5
FEMA No. 2886
Hydratropa aldehyde
Hydrotropic aldehyde
alpha-Methyl phenylacetaldehyde
alpha-Methylbenzenealdehydealpha-
alpha-Methyltolualdehyde
alpha-Phenyl propionaldehyde
2-Phenyl propionaldehyde
alpha-Phenylpropanal
2-Phenyl-1-propanal
Propionaldehyde, 2-phenyl-
alpha-Tolualdehyde, alpha-methyl-
2-Fenyl-1-propanal
Aldehyd hydratropovy
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3730701
Frequently Asked Questions
Is HYDRATROPIC ALDEHYDE allowed in the EU?
HYDRATROPIC ALDEHYDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does HYDRATROPIC ALDEHYDE do in cosmetics?
HYDRATROPIC ALDEHYDE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 93-53-8.
What is the NOAEL for HYDRATROPIC ALDEHYDE?
The NOAEL (No Observed Adverse Effect Level) for HYDRATROPIC ALDEHYDE is 10 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Is HYDRATROPIC ALDEHYDE used outside cosmetics?
HYDRATROPIC ALDEHYDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HYDRATROPIC ALDEHYDE have different safety status in cosmetics vs industrial chemicals?
HYDRATROPIC ALDEHYDE is classified GHS CMR hazard (H315, H317, H319, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check HYDRATROPIC ALDEHYDE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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