Is 2-Acetonaphthone safe in cosmetics?
2-Acetonaphthone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
2-Acetonaphthone
Also known as: 4-07-00-01294, beta-Acetylnaphthalene, BRN 0774965, Cetone D, EINECS 202-216-2 (+9 more)
INCI: 2-ACETONAPHTHONE
2-Acetonaphthone (CAS 93-08-3) is a cosmetic cosmetic ingredient functioning as Masking, Perfuming. NOAEL 33 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 93-08-3 →
Auto-generated CPSR Part A draft with source citations
Function
Masking, Perfuming
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-naphthalen-2-ylethanone
InChIKey
XSAYZAUNJMRRIR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Acetonaphthone.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 2-Acetonaphthone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 36.9 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2-Acetonaphthone across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1296 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (6)
JECFA Number
811
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-ACETYL NAPHTHALENE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/61 | FAS 48-JECFA 57/117
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
METHYL 2-NAPHTHYL KETONE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/61 | FAS 48-JECFA 57/117
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CETONE D | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/61 | FAS 48-JECFA 57/117
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
METHYL beta-NAPHTHYL KETONE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/61 | FAS 48-JECFA 57/117
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for 2-Acetonaphthone.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-Acetonaphthone by CAS number or substance name.
Studies
1
Lowest NOAEL
36.9 mg/kg bw/day
Highest NOAEL
36.9 mg/kg bw/day
COSMOS_DB
Known Synonyms
4-07-00-01294
beta-Acetylnaphthalene
BRN 0774965
Cetone D
EINECS 202-216-2
FEMA No. 2723
Ketone, methyl 2-naphthyl
beta-Naphthyl methyl ketone
Oranger crystals
Oranger cyrstals
UNII-21D49LOP2T
Methyl beta-naphthyl ketone
beta-acetonaphthalene
beta-acetonaphthone
Chemical Function
Deodorizer
Fragrance
Flavouring and nutrient
Regulatory Lists
SCIL (9/2019)
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183700
Frequently Asked Questions
Is 2-Acetonaphthone allowed in the EU?
2-Acetonaphthone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Acetonaphthone do in cosmetics?
2-Acetonaphthone functions as: Masking, Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 93-08-3.
What is the NOAEL for 2-Acetonaphthone?
The NOAEL (No Observed Adverse Effect Level) for 2-Acetonaphthone is 36.9 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Is 2-Acetonaphthone used outside cosmetics?
2-Acetonaphthone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Acetonaphthone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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