What is the NOAEL for Hydratropaldehyde?
Hydratropaldehyde has 45 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hydratropaldehyde
Also known as: 2-Phenylpropanal, Hydratropic aldehyde, Benzeneacetaldehyde, .alpha.-methyl-, Benzeneacetaldehyde, alpha-methyl-, Benzeneacetalaldehyde, alpha-methyl- (+15 more)
CAS 93-53-8
Hydratropaldehyde (CAS 93-53-8) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Hydratropic Aldehyde (2-Phenylpropanal) →
Cross-Vertical Regulatory Divergence
Hydratropaldehyde is classified GHS CMR hazard (H315, H317, H319, H361) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
45
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Hydratropaldehyde
CAS Number
93-53-8
DTXSID
DTXSID0052629
Molecular Formula
C9H10O
InChI Key
IQVAERDLDAZARL-UHFFFAOYSA-N
Monoisotopic Mass
134.073165
Synonyms
2-PhenylpropanalHydratropic aldehydeBenzeneacetaldehyde, .alpha.-methyl-Benzeneacetaldehyde, alpha-methyl-Benzeneacetalaldehyde, alpha-methyl-EINECS 202-255-5FEMA No. 2886Hydratropa aldehydeHydrotropic aldehydealpha-Methyl phenylacetaldehydealpha-Methylbenzenealdehydealpha-alpha-Methyltolualdehyde
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 45 of 45 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 44.5 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 4 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 28 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 38.2 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 37.9 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 40.8 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.875 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.5 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 26.6 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 48.2 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 5.1 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 21.2 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 15.85 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 34.7 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 26 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 48.23 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 64.8 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 6.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 6.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 6.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 6.3 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 8JKX55PKZQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8JKX55PKZQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8JKX55PKZQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8JKX55PKZQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 112 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 167.6 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 195.1 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 3.449 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 9.1 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 14.3 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 14.29 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 1550 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 542.5 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| =2800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =75 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 10 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =10 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =25 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 45 of 45 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hydratropaldehyde | 202-255-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3730701
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Hydratropaldehyde?
Hydratropaldehyde appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Hydratropaldehyde used in cosmetics?
Yes, Hydratropaldehyde is also indexed as a cosmetic ingredient under the name Hydratropic Aldehyde (2-Phenylpropanal). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hydratropaldehyde come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Hydratropaldehyde have different safety status in cosmetics vs industrial chemicals?
Hydratropaldehyde is classified GHS CMR hazard (H315, H317, H319, H361) in the chemicals database but is restricted in EU cosmetics.
Is Hydratropaldehyde used outside industrial chemicals?
Hydratropaldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.