NOAEL Studies Cosmetic Ingredient

HYDRATROPIC ALDEHYDE NOAEL Studies

CAS: 93-53-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 105 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 10 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =50 mg/kg bw/day Rat oral: gavage 105 days chronic/long term toxicity EFSA FEEDAP - 2017 - OutputID 2920 - organ weights - systemic - Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species - doi:10.2903/j.efsa.2017.4672
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2800 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11538; row=1532; data_type=In Vivo; mixture=Chemical; chemical_name=Hydratropaldehyde; preferred_name=Hydratropaldehyde; dtxsid=DTXSID0052629; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 33 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 44.5 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3151; Record_ID=skin_sensitization_invitro_732; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=44.5; Reported_Response_Unit=ug/mL; Response=44.5; Response_Unit=ug/mL; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Takenouchi et al. 2013; 23824015; 10.2131/jts.38.599|Nukada personal communication (undated)|Takenouchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization CD86, EC150 28 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3136; Record_ID=skin_sensitization_invitro_730; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=28; Reported_Response_Unit=ug/mL; Response=28; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization CD86, EC150 38.2 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3149; Record_ID=skin_sensitization_invitro_732; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=38.200000000000003; Reported_Response_Unit=ug/mL; Response=38.2; Response_Unit=ug/mL; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Takenouchi et al. 2013; 23824015; 10.2131/jts.38.599|Nukada personal communication (undated)|Takenouchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization CD86, EC150 4 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8240; Record_ID=skin_sensitization_invitro_2263; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=29.81070204; Reported_Response_Unit=uM; Conversion_Factor_Value=134.178; Conversion_Factor_Source=EPA Dashboard; Converted_Response=4; Converted_Response_Unit=ug/mL; Response=4; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization CV75 40.8 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3138; Record_ID=skin_sensitization_invitro_730; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=h-CLAT; Endpoint=CV75; Reported_Response=40.799999999999898; Reported_Response_Unit=ug/mL; Response=40.8; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization CV75 37.9 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3146; Record_ID=skin_sensitization_invitro_732; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=h-CLAT; Endpoint=CV75; Reported_Response=37.9; Reported_Response_Unit=ug/mL; Response=37.9; Response_Unit=ug/mL; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Takenouchi et al. 2013; 23824015; 10.2131/jts.38.599|Nukada personal communication (undated)|Takenouchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 0.875 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11101; Record_ID=skin_sensitization_invivo_2427; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.875; Response_Unit=%; Species=Human; Route=Dermal; Reference=Hill Top Research Institute, Inc. 1991; Not available; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Concentration, one positive response 2.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11097; Record_ID=skin_sensitization_invivo_2427; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=2.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Hill Top Research Institute, Inc. 1991; Not available; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Depletion Cys 26.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=982; Record_ID=skin_sensitization_invitro_269; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=26.6; Reported_Response_Unit=%; Response=26.6; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Depletion Cys 48.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=990; Record_ID=skin_sensitization_invitro_271; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=48.2; Reported_Response_Unit=%; Response=48.2; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska supp A 2013; 21993957; 10.14573/altex.2011.3.211|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Takenouchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Depletion Lys 5.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=981; Record_ID=skin_sensitization_invitro_269; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=5.0999999999999996; Reported_Response_Unit=%; Response=5.1; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Depletion Lys 21.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=989; Record_ID=skin_sensitization_invitro_271; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=21.2; Reported_Response_Unit=%; Response=21.2; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska supp A 2013; 21993957; 10.14573/altex.2011.3.211|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Takenouchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Depletion Lys + Cys 15.85 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=983; Record_ID=skin_sensitization_invitro_269; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=15.85; Reported_Response_Unit=%; Response=15.85; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Depletion Lys + Cys 34.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=991; Record_ID=skin_sensitization_invitro_271; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=34.700000000000003; Reported_Response_Unit=%; Response=34.7; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska supp A 2013; 21993957; 10.14573/altex.2011.3.211|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Takenouchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization EC1.5 26 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7047; Record_ID=skin_sensitization_invitro_1660; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=26; Reported_Response_Unit=uM; Response=26; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization EC1.5 64.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7048; Record_ID=skin_sensitization_invitro_1642; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=64.8; Reported_Response_Unit=uM; Response=64.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization EC1.5 48.23 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7596; Record_ID=skin_sensitization_invitro_1835; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=LuSens; Endpoint=EC1.5; Reported_Response=48.22530864; Reported_Response_Unit=uM; Response=48.23; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization EC3 6.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13449; Record_ID=skin_sensitization_invivo_3599; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=LLNA; Endpoint=EC3; Response=6.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization EC3 6.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13449; Record_ID=skin_sensitization_invivo_3599; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=LLNA; Endpoint=EC3; Response=6.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization EC3 6.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13449; Record_ID=skin_sensitization_invivo_3599; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=LLNA; Endpoint=EC3; Response=6.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization EC3 6.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13449; Record_ID=skin_sensitization_invivo_3599; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=LLNA; Endpoint=EC3; Response=6.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization IC50 167.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7049; Record_ID=skin_sensitization_invitro_1660; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=167.6; Reported_Response_Unit=uM; Response=167.6; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization IC50 195.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7050; Record_ID=skin_sensitization_invitro_1642; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=195.1; Reported_Response_Unit=uM; Response=195.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization IC50 112 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7666; Record_ID=skin_sensitization_invitro_1835; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=LuSens; Endpoint=IC50; Reported_Response=112.0288279; Reported_Response_Unit=uM; Response=112; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Imax 9.1 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6933; Record_ID=skin_sensitization_invitro_1642; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.1; Reported_Response_Unit=Unitless; Response=9.1; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Imax 14.3 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7051; Record_ID=skin_sensitization_invitro_1660; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=14.3; Reported_Response_Unit=Unitless; Response=14.3; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Imax 3.449 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7569; Record_ID=skin_sensitization_invitro_1835; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=LuSens; Endpoint=Imax; Reported_Response=3.448506804; Reported_Response_Unit=Unitless; Response=3.449; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Incidence of positive responses 14.29 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11093; Record_ID=skin_sensitization_invivo_2427; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=14.29; Response_Unit=%; Species=Human; Route=Dermal; Reference=Hill Top Research Institute, Inc. 1991; Not available; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11139; Record_ID=skin_sensitization_invivo_2425; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90013-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Induction dose per skin area 1550 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11091; Record_ID=skin_sensitization_invivo_2427; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=1550; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Hill Top Research Institute, Inc. 1991; Not available; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Induction dose per skin area 1296 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11138; Record_ID=skin_sensitization_invivo_2425; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90013-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 542.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11103; Record_ID=skin_sensitization_invivo_2427; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=542.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Hill Top Research Institute, Inc. 1991; Not available; Not available|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11088; Record_ID=skin_sensitization_invivo_2425; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0052629; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90013-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0052629
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =75 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc26e4b0a7c65d229232; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18689/7/6/2?documentUUID=9da31b3a-26bd-4dd4-a7d0-4d7bc8d82db1; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836952_15836953:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9214ecb4408bd27ba3a37644f0d43bb9
ToxValDB_ECHA_IUCLID NOAEL =10 mg/kg bw/day Rat oral chronic; 15 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf70e4b0a7c65d1cdf3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18689/7/6/2?documentUUID=9da31b3a-26bd-4dd4-a7d0-4d7bc8d82db1; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15830426:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed829a2fbdea1688a806abd76be73a6a
ToxValDB_ECHA_IUCLID NOAEL =25 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc26e4b0a7c65d229232; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18689/7/6/2?documentUUID=9da31b3a-26bd-4dd4-a7d0-4d7bc8d82db1; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836952_15836953:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_78b422e2bd0128c8f3bc1e78f7eecf45
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =50 mg/kg bw/day Rat oral chronic; 15 weeks chronic LONG_REF=EFSA FEEDAP (2017). Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species. doi:10.2903/j.efsa.2017.4672.; TITLE=Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2017.4672; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA:15620806:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f38eba34e501b90abc6c40fb8e8452b8
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8JKX55PKZQ UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8JKX55PKZQ"}
openFDA substances FDA UNII substance identifier 8JKX55PKZQ UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8JKX55PKZQ"}
openFDA substances FDA UNII substance identifier 8JKX55PKZQ UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8JKX55PKZQ"}
openFDA substances FDA UNII substance identifier 8JKX55PKZQ UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8JKX55PKZQ"}