Is Heparin safe in cosmetics?
Heparin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Heparin
Also known as: Semuloparin, Tinzaparin, α-Heparin, Vitrum AB, Dalteparin (+4 more)
INCI: HEPARIN
Heparin (CAS 9005-49-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning. Reported NOAEL =3 mg/kg bw/day in dog (Beagle; male/female) (FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 9005-49-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted as cosmetic ingredient but heparin is primarily regulated as a drug (anticoagulant) by FDA; cosmetic use must not make drug claims
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Heparin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Heparin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =3 mg/kg bw/day | subcutaneous | dog (Beagle; male/female) | repeated dose toxicity other | FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z |
| NOAEL | =5 mg/kg bw/day | intravenous | monkey (other:; male/female) | repeated dose toxicity other | FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Heparin.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Heparin by CAS number or substance name.
Studies
2
Lowest NOAEL
3 mg/kg bw/day
Highest NOAEL
5 mg/kg bw/day
FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z
Known Synonyms
Semuloparin
Tinzaparin
α-Heparin
Vitrum AB
Dalteparin
Heparin sulfate
EC No.: 232-681-7
EINECS 232-681-7
232-681-7
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
heparin
ChEMBL ID
CHEMBL1201513
Adverse Event Associations
5228
Frequently Asked Questions
Is Heparin allowed in the EU?
Heparin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Heparin do in cosmetics?
Heparin functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9005-49-6.
What is the NOAEL for Heparin?
The NOAEL (No Observed Adverse Effect Level) for Heparin is =3 mg/kg bw/day based on a repeated dose toxicity other study via subcutaneous route in dog (Beagle; male/female). A total of 2 study endpoints are available. Source: FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z.
Is Heparin used outside cosmetics?
Heparin also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Heparin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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