Good Cosmetic Ingredient NOAEL Data

Alginate (Sodium Alginate)

Also known as: Algiline, L'-Algiline, Algin (Laminaria spp. and other kelps), Algipon L-1168, Cohasal-IH (+8 more)

INCI: SODIUM ALGINATE

Alginate (Sodium Alginate) (CAS 9005-38-3) is a cosmetic cosmetic ingredient functioning as Thickener. Reported NOAEL =1.8 mg/kg bw/day in Rat (EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.

View industrial chemical safety profile for CAS 9005-38-3 →

Auto-generated CPSR Part A draft with source citations
Function
Thickener
Safety Rating
GOOD

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes No warnings or adverse event alerts exist for sodium alginate in cosmetic formulations.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Alginate (Sodium Alginate).

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Alginate (Sodium Alginate). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =1.8 mg/kg bw/day oral: feed Rat subchronic EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx

EPA ToxValDB — Toxicity Values

1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint Value Species Route Duration Source
LD50 >5000 mg/kg Rat oral - ChemIDplus

Additional Ingredient Properties

3 property records from structured ingredient metadata.

biopolymer
{"cas_number": "9005-38-3", "polymer_class": "seaweed_polysaccharide", "botanical_source": "Brown seaweed (sodium salt)", "molecular_weight_range_kDa": "32-400", "monosaccharide_composition": "sodium mannuronate/guluronate", "degree_of_branching": "linear", "charge_type": "anionic", "viscosity_1pct_solution_mPas": "20-400", "pseudoplastic_behavior": "moderate", "thixotropy": "weak", "yield_stress_…
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "20", "estimated_cost_per_kg_usd_high": "38", "natural_premium_markup_pct": "28", "organic_certified_premium_pct": "50", "supply_chain_volatility": "medium", "primary_source_region": "China/Norway", "synthetic_vs_natural_cost_ratio": "2.0", "bulk_discount_threshold_kg": "100", "seasonal_price_variation": "medium", "commodity_or_specialty"…
polymer
{"cas_number": "9005-38-3", "ingredient_class": "thickener/gelling_agent", "polymer_type": "natural_polysaccharide", "chemical_backbone": "other", "molecular_weight_Da_range": "32000-400000", "ionic_character": "anionic", "gel_strength_Pa": "moderate_high", "pH_viscosity_sensitivity": "moderate", "salt_tolerance": "moderate", "electrolyte_effect_on_viscosity": "moderate", "temperature_viscosity_se…

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Binder Emulsifier Flavouring and nutrient Fragrance Processing aids not otherwise specified Stabilizing agent Surfactant (surface active agent) Thickening agent Viscosity modifier
Regulatory List Membership (4)
EU Regulated in Personal Care EU Restricted for Children (Cosmetics) IFRA Fragrance Transparency List FDA Substances Added to Food (EAFUS)

Expert Verdict

Expert safety assessment and concern-level summary for Alginate (Sodium Alginate).

Regulatory Flags

eu_children_restricted ifra_fragrance fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Alginate (Sodium Alginate) by CAS number or substance name.

Studies
1
Lowest NOAEL
1.8 mg/kg bw/day
Highest NOAEL
1.8 mg/kg bw/day
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx

Known Synonyms

Algiline L'-Algiline Algin (Laminaria spp. and other kelps) Algipon L-1168 Cohasal-IH Duckalgin FEMA No. 2014 Manucol SS/LD2 Manutex Manutex RS-5 Manutex rS1 Sodium polymannuronate UNII-C269C4G2ZQ

Chemical Function

Viscosity modifier Binder Fragrance Flavouring and nutrient Thickening agent Processing aids not otherwise specified Emulsifier

Regulatory Lists

children; Europe; Personal care children; Europe; Personal care - dental care - toothpaste Europe; Personal care Europe; Personal care IFRA Transparency food_additive; Substances Added to Food (formerly EAFUS) (2/2019) Canada; consumer_product; Substances in Products - Canada (4/2014) inert_ingredient; Pesticides inert_ingredient; non_food_use; Pesticides

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA count match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Adverse Event Associations
188
View full pharmaceutical profile →

Frequently Asked Questions

Is Alginate (Sodium Alginate) safe in cosmetics?

Alginate (Sodium Alginate) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is Alginate (Sodium Alginate) allowed in the EU?

Alginate (Sodium Alginate) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Alginate (Sodium Alginate) do in cosmetics?

Alginate (Sodium Alginate) functions as: Thickener. It is classified as a cosmetic ingredient in our database. CAS number: 9005-38-3.

What is the NOAEL for Alginate (Sodium Alginate)?

The NOAEL (No Observed Adverse Effect Level) for Alginate (Sodium Alginate) is =1.8 mg/kg bw/day based on a subchronic study via oral: feed route in Rat. Source: EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx.

Is Alginate (Sodium Alginate) used outside cosmetics?

Alginate (Sodium Alginate) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

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