NOAEL Studies
Cosmetic Ingredient
Heparin NOAEL Studies
INCI: HEPARIN
CAS: 9005-49-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z | NOAEL | =3 | mg/kg bw/day | dog (Beagle; male/female) | subcutaneous | 13 weeks | repeated dose toxicity other | d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z - RepeatedDoseToxicityOther - 13-week subcutaneous toxicity study in dogs_5 - eff70d7d-1286-4c61-b6bb-c997f7a8a1e3/de60c134-f95e-4057-8fb1-2c7262b956ab - basis: other: |
| FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z | NOAEL | =5 | mg/kg bw/day | monkey (other:; male/female) | intravenous | 26 weeks | repeated dose toxicity other | d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z - RepeatedDoseToxicityOther - 26-week intravenous toxicity study in monkeys_7 - a69bf59c-2793-4c25-875f-af3b02c02ec0/de60c134-f95e-4057-8fb1-2c7262b956ab - basis: other: |
| FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z | NOEL | <=30 | mg/kg bw/day | rat (Sprague-Dawley; male/female) | subcutaneous | GD 6-15 | developmental toxicity teratogenicity | d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z - DevelopmentalToxicityTeratogenicity - Segment II: subcutaneous teratological study in rats_2 - 4e2468bc-b147-4d37-b22c-51dd817f4d25/de60c134-f95e-4057-8fb1-2c7262b956ab - basis: pre and post implantation loss: no abnormal phenotype detected |
| FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z | NOEL | <=20 | mg/kg bw/day | rat (Wistar; male/female) | subcutaneous | 14 days | repeated dose toxicity other | d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z - RepeatedDoseToxicityOther - 14-day SC dose range finding study in rats_1 - 2bb811ff-e2f6-4a57-a0b5-c78906a7b689/de60c134-f95e-4057-8fb1-2c7262b956ab - basis: organ weights and organ / body weight ratios: no abnormal phenotype detected |
| FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z | NOEL | <=160 | mg/kg bw/day | rat (Sprague-Dawley; male/female) | intravenous | GD 6-15 | developmental toxicity teratogenicity | d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z - DevelopmentalToxicityTeratogenicity - Segment II: intravenous teratology study in rats_3 - 130f4045-5ea7-48b3-b268-5b21466c6634/de60c134-f95e-4057-8fb1-2c7262b956ab - basis: body weight and weight gain: no abnormal phenotype detected |
| FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z | NOEL | <=15 | mg/kg bw/day | rat (Wistar; male/female) | subcutaneous | 13 weeks | repeated dose toxicity other | d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z - RepeatedDoseToxicityOther - 13-week SC toxicity study in rats_ - 462234c3-2e9f-4b83-b405-83df4852e01d/de60c134-f95e-4057-8fb1-2c7262b956ab - basis: food consumption and compound intake: no abnormal phenotype detected |
| FDA_Toxicity_d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z | NOEL | <=90 | mg/kg bw/day | rat (Sprague-Dawley; male/female) | intravenous | 26 weeks | repeated dose toxicity other | d87e80d0-be6e-4688-8dd8-c85780d7157d_dossier.i6z - RepeatedDoseToxicityOther - 26-week intravenous toxicity study in rats_ - 80764e6a-d07c-4117-b122-842b0eb62880/de60c134-f95e-4057-8fb1-2c7262b956ab - basis: food consumption and compound intake: no abnormal phenotype detected |
openFDA substances 48 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | E47C0NF7LV | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"E47C0NF7LV"} |
| openFDA substances | FDA UNII substance identifier | S79O08V79F | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"S79O08V79F"} |
| openFDA substances | FDA UNII substance identifier | 1K5KDI46KZ | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"1K5KDI46KZ"} |
| openFDA substances | FDA UNII substance identifier | M316WT19D8 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"M316WT19D8"} |
| openFDA substances | FDA UNII substance identifier | 9816XA9004 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"9816XA9004"} |
| openFDA substances | FDA UNII substance identifier | V72OT3K19I | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"V72OT3K19I"} |
| openFDA substances | FDA UNII substance identifier | 5R0L1D739E | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"5R0L1D739E"} |
| openFDA substances | FDA UNII substance identifier | VL0L558GCB | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"VL0L558GCB"} |
| openFDA substances | FDA UNII substance identifier | T2410KM04A | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"T2410KM04A"} |
| openFDA substances | FDA UNII substance identifier | P776JQ4R2F | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P776JQ4R2F"} |
| openFDA substances | FDA UNII substance identifier | 7UQ7X4Y489 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"7UQ7X4Y489"} |
| openFDA substances | FDA UNII substance identifier | 4QW4AN84NQ | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"4QW4AN84NQ"} |
| openFDA substances | FDA UNII substance identifier | E47C0NF7LV | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"E47C0NF7LV"} |
| openFDA substances | FDA UNII substance identifier | E47C0NF7LV | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"E47C0NF7LV"} |
| openFDA substances | FDA UNII substance identifier | S79O08V79F | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"S79O08V79F"} |
| openFDA substances | FDA UNII substance identifier | S79O08V79F | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"S79O08V79F"} |
| openFDA substances | FDA UNII substance identifier | 1K5KDI46KZ | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"1K5KDI46KZ"} |
| openFDA substances | FDA UNII substance identifier | 1K5KDI46KZ | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"1K5KDI46KZ"} |
| openFDA substances | FDA UNII substance identifier | M316WT19D8 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"M316WT19D8"} |
| openFDA substances | FDA UNII substance identifier | M316WT19D8 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"M316WT19D8"} |
| openFDA substances | FDA UNII substance identifier | 9816XA9004 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"9816XA9004"} |
| openFDA substances | FDA UNII substance identifier | 9816XA9004 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"9816XA9004"} |
| openFDA substances | FDA UNII substance identifier | V72OT3K19I | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"V72OT3K19I"} |
| openFDA substances | FDA UNII substance identifier | V72OT3K19I | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"V72OT3K19I"} |
| openFDA substances | FDA UNII substance identifier | 5R0L1D739E | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"5R0L1D739E"} |
| openFDA substances | FDA UNII substance identifier | 5R0L1D739E | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"5R0L1D739E"} |
| openFDA substances | FDA UNII substance identifier | VL0L558GCB | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"VL0L558GCB"} |
| openFDA substances | FDA UNII substance identifier | VL0L558GCB | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"VL0L558GCB"} |
| openFDA substances | FDA UNII substance identifier | T2410KM04A | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"T2410KM04A"} |
| openFDA substances | FDA UNII substance identifier | T2410KM04A | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"T2410KM04A"} |
| openFDA substances | FDA UNII substance identifier | E47C0NF7LV | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"E47C0NF7LV"} |
| openFDA substances | FDA UNII substance identifier | S79O08V79F | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"S79O08V79F"} |
| openFDA substances | FDA UNII substance identifier | 1K5KDI46KZ | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"1K5KDI46KZ"} |
| openFDA substances | FDA UNII substance identifier | M316WT19D8 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"M316WT19D8"} |
| openFDA substances | FDA UNII substance identifier | 9816XA9004 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"9816XA9004"} |
| openFDA substances | FDA UNII substance identifier | V72OT3K19I | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"V72OT3K19I"} |
| openFDA substances | FDA UNII substance identifier | 5R0L1D739E | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"5R0L1D739E"} |
| openFDA substances | FDA UNII substance identifier | P776JQ4R2F | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P776JQ4R2F"} |
| openFDA substances | FDA UNII substance identifier | P776JQ4R2F | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P776JQ4R2F"} |
| openFDA substances | FDA UNII substance identifier | VL0L558GCB | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"VL0L558GCB"} |
| openFDA substances | FDA UNII substance identifier | T2410KM04A | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"T2410KM04A"} |
| openFDA substances | FDA UNII substance identifier | 7UQ7X4Y489 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"7UQ7X4Y489"} |
| openFDA substances | FDA UNII substance identifier | P776JQ4R2F | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P776JQ4R2F"} |
| openFDA substances | FDA UNII substance identifier | 7UQ7X4Y489 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"7UQ7X4Y489"} |
| openFDA substances | FDA UNII substance identifier | 4QW4AN84NQ | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"4QW4AN84NQ"} |
| openFDA substances | FDA UNII substance identifier | 4QW4AN84NQ | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"4QW4AN84NQ"} |
| openFDA substances | FDA UNII substance identifier | 7UQ7X4Y489 | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"7UQ7X4Y489"} |
| openFDA substances | FDA UNII substance identifier | 4QW4AN84NQ | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"4QW4AN84NQ"} |