Cosmetic cross-reference

Heparin

CAS 9005-49-6

Heparin (CAS 9005-49-6) is a pharmaceutical compound with 3 bioactivity targets and 5,228 adverse event associations.

SOURCE NLM DailyMed

Label records

SOURCE EMBL-EBI ChEMBL

Bioactivity

SOURCE DrugCentral

Adverse signals

5,228

SOURCE IUPHAR/BPS

PubMed IDs

SOURCE DrugCentral 055904D152D6

Compound Identity

Matched identifiers and naming fields for the pharmaceutical compound record.

Primary Name

Heparin

CAS Number

9005-49-6

UNII

T2410KM04A

ChEMBL ID

CHEMBL1201513

DrugCentral Struct ID

1358

Source Match

DrugCentral (CAS), FDA GSRS (UNII)

SOURCE Ingredients table / CosIng profile same-CAS cross-reference

Cross-Reference to Cosmetics

Same-CAS ingredient record found in the cosmetics vertical.

This substance also has a cosmetic safety profile →

SOURCE EMBL-EBI ChEMBL 3 bioactivity rows

Bioactivity & Target Interactions

Target-level activity records with assay counts, activity type, and measured value where present.

Target	Activity	Value	Assays	Organism
Antithrombin-III Secreted	Kd	7.85	-	Homo sapiens
Spike glycoprotein Glycoprotein	Kd	10.14	-	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Spike glycoprotein, S glycoprotein Unclassified	Kd	6.3	-	Severe acute respiratory syndrome coronavirus

SOURCE DrugCentral 80 associations

Adverse Event Associations

DrugCentral / FAERS disproportionality signal rows matched to this compound.

Reaction PT	Drug AE	LLR	MedDRA
Heparin-induced thrombocytopenia	1769	7070.85	10062506
Vascular stent thrombosis	294	878.837	10063934
Haemorrhage	836	763.037	10055798
Haemorrhage intracranial	428	638.457	10018985
Thrombocytopenia	1206	536.531	10043554
Haematoma	487	508.316	10018852
Cerebral haemorrhage	509	502.882	10008111
Labelled drug-drug interaction medication error	354	495.783	10064373
Premature baby	470	470.13	10036590
Cardiogenic shock	395	441.49	10007625
Multiple organ dysfunction syndrome	670	435.734	10077361
Shock haemorrhagic	288	428.826	10049771
Thrombosis	588	393.227	10043607
Premature delivery	304	368.093	10036595
Arthralgia	257	351.564	10003239
Joint swelling	44	346.155	10023232
Thrombosis in device	168	345.277	10062546
Retroperitoneal haematoma	159	343.332	10058360
Pulmonary embolism	757	330.126	10037377
Rheumatoid arthritis	12	327.023	10039073
Retroperitoneal haemorrhage	153	317.336	10038980
Hereditary angioedema	173	311.049	10019860
Low birth weight baby	224	284.672	10067508
Post procedural haemorrhage	203	283.513	10051077
Arthropathy	16	278.733	10003285
Alopecia	66	275.154	10001760
Appendicolith	156	274.119	10074458
Cardiac tamponade	164	267.656	10007610
Ventricular fibrillation	268	266.736	10047290
Fatigue	768	253.5	10016256
Drug intolerance	83	252.163	10061822
Activated partial thromboplastin time prolonged	183	251.12	10000636
Completed suicide	10	250.298	10010144
Acute kidney injury	1369	245.744	10069339
Pain	513	240.548	10033371
Coagulation time shortened	63	237.069	10009800
Abdominal discomfort	101	229.878	10000059
Pemphigus	5	229.293	10034280
Haemothorax	125	228.422	10019027
Glossodynia	4	226.74	10018388
Sepsis	897	222.537	10040047
Cardiac arrest	593	202.329	10007515
Haematoma muscle	84	192.371	10055890
Systemic lupus erythematosus	29	191.76	10042945
Heparin resistance	38	187.217	10059598
Appendicitis	185	187.101	10003011
Coagulation time prolonged	85	186.55	10009799
Subarachnoid haemorrhage	195	183.519	10042316
Compartment syndrome	102	182.737	10010121
Procedural haemorrhage	103	182.086	10071229

Association rows are source-linked signal records, not incidence rates or clinical causality claims.

SOURCE IUPHAR/BPS 5 interactions

IUPHAR Ligand-Target Data

Curated ligand-target interaction rows with action, affinity, and literature identifiers.

Target	Action	Affinity	PubMed
serpin family C member 1 SERPINC1	Activation	7.849999904632568 pKd	23598032
serpin family C member 1 SERPINC1	Activation	-	7528134
CoV Spike glycoprotein S	Binding	6.300000190734863 pKd	32653452
CoV Spike glycoprotein	Binding	9.0 pKd	32653452
CoV Spike glycoprotein S	Binding	10.140000343322754 pKd	32653452

SOURCE PharmGKB 2 phenotype rows

Pharmacogenomics

Drug-gene phenotype annotations and evidence levels from PharmGKB-mapped rows.

HLA-DRB3 (PA35074) HLA-DRB3*01:01:02:01

HLA-DRB3 *01:01:02:01 is associated with increased likelihood of heparin-induced thrombocytopenia when treated with heparin.

Evidence: -; PMID 28688202

HLA-DRB3 HLA-DRB3*01:01

Heparin-induced thrombocytopenia

Evidence: 3; PMID 1

SOURCE NLM RxNorm 4 name rows

Drug Names / RxNorm

Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.

Name	RxCUI	Type	Source
HEPARIN	235473	SU	MTHSPL
heparin	235473	SU	MTHSPL
Heparin	235473	SU	MTHSPL
heparin	5224	IN	RXNORM

SOURCE SIDER 80 side-effect rows

Side Effects

SIDER side-effect terms mapped to the drug or same-CAS compound identity.

Side Effect	Drug Name	MedDRA Type	Concept ID
Acute coronary syndrome	heparin	PT	C0948089
Adrenal haemorrhage	heparin	LLT	C0151693
Adrenal haemorrhage	heparin	PT	C0151693
Adrenocortical insufficiency acute	heparin	LLT	C0151467
Adrenocortical insufficiency acute	heparin	PT	C0151467
Alopecia	heparin	LLT	C0002170
Alopecia	heparin	PT	C0002170
Anaphylactic shock	heparin	PT	C0002792
Anaphylactoid reaction	heparin	LLT	C0340865
Anaphylactoid reaction	heparin	PT	C0340865
Asthma	heparin	LLT	C0004096
Asthma	heparin	PT	C0004096
Body temperature increased	heparin	LLT	C0015967
Body temperature increased	heparin	PT	C0015967
Cardiac failure congestive	heparin	LLT	C0018802
Cardiac failure congestive	heparin	PT	C0018802
Cerebrovascular accident	heparin	LLT	C0038454
Cerebrovascular accident	heparin	PT	C0038454
Chills	heparin	LLT	C0085593
Chills	heparin	PT	C0085593
Coagulation time prolonged	heparin	LLT	C0151563
Coagulation time prolonged	heparin	PT	C0151563
Cyanosis	heparin	LLT	C0010520
Cyanosis	heparin	PT	C0010520
Erythema	heparin	LLT	C0041834
Erythema	heparin	PT	C0041834
Extravasation	heparin	LLT	C0015376
Extravasation	heparin	PT	C0015376
Fluid overload	heparin	LLT	C0546817
Fluid overload	heparin	PT	C0546817
Fluid retention	heparin	PT	C0268000
Gangrene	heparin	LLT	C0017086
Gangrene	heparin	PT	C0017086
Haematoma	heparin	LLT	C0018944
Haematoma	heparin	PT	C0018944
Haemoglobin	heparin	PT	C0518015
Haemorrhage	heparin	LLT	C0019080
Haemorrhage	heparin	PT	C0019080
Haemorrhage urinary tract	heparin	LLT	C0235620
Haemorrhage urinary tract	heparin	PT	C0235620
Headache	heparin	LLT	C0018681
Headache	heparin	PT	C0018681
Heparin-induced thrombocytopenia	heparin	LLT	C0272285
Heparin-induced thrombocytopenia	heparin	PT	C0272285
Hyperlipidaemia	heparin	LLT	C0020473
Hyperlipidaemia	heparin	PT	C0020473
Hypernatraemia	heparin	LLT	C0020488
Hypernatraemia	heparin	PT	C0020488
Hypersensitivity	heparin	LLT	C0020517
Hypersensitivity	heparin	PT	C0020517
Infection	heparin	LLT	C0009450
Infection	heparin	PT	C0009450
Injection site irritation	heparin	LLT	C0521498
Injection site irritation	heparin	PT	C0521498
Lacrimation	heparin	LLT	C0423153
Lacrimation increased	heparin	PT	C0152227
Myocardial infarction	heparin	LLT	C0027051
Myocardial infarction	heparin	PT	C0027051
Nausea	heparin	LLT	C0027497
Nausea	heparin	PT	C0027497
Necrosis	heparin	LLT	C0027540
Necrosis	heparin	PT	C0027540
Oedema	heparin	LLT	C0013604
Oedema	heparin	PT	C0013604
Osteoporosis	heparin	LLT	C0029456
Osteoporosis	heparin	PT	C0029456
Pain	heparin	LLT	C0030193
Pain	heparin	PT	C0030193
Phlebitis	heparin	LLT	C0031542
Phlebitis	heparin	PT	C0031542
Priapism	heparin	LLT	C0033117
Priapism	heparin	PT	C0033117
Pruritus	heparin	LLT	C0033774
Pruritus	heparin	PT	C0033774
Retroperitoneal haemorrhage	heparin	LLT	C0151705
Retroperitoneal haemorrhage	heparin	PT	C0151705
Rhinitis	heparin	LLT	C0035455
Rhinitis	heparin	PT	C0035455
Shock	heparin	LLT	C0036974
Shock	heparin	PT	C0036974

SOURCE Rendered pharma page rows FAQPage JSON-LD

Frequently Asked Questions

Short answers generated only from the same visible source-linked rows on this page.

What is Heparin used for in pharmaceutical contexts?

Heparin (CAS 9005-49-6) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.

What are the known adverse events for Heparin?

Heparin has 5,228 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Heparin-induced thrombocytopenia, Vascular stent thrombosis, Haemorrhage, Haemorrhage intracranial, Thrombocytopenia. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.

Is Heparin also used in cosmetics?

Yes. The ingredients table has a same-CAS cosmetic profile for Heparin with EU status "permitted".

What clinical phase is Heparin in?

No phase 1-4 clinical development badge is rendered for Heparin because the matched compound identifier rows do not contain a max-phase value.

What bioactivity targets are documented for Heparin?

Heparin has 3 bioactivity rows in this page query. Rendered target entries include Antithrombin-III, Spike glycoprotein, Spike glycoprotein, S glycoprotein.