Is HEMA safe in cosmetics?
HEMA has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted. 2 toxicological study endpoint(s) are available in our database.
HEMA
Also known as: 2-propenoic acid, 2-methyl-, 2-hydroxyethyl ester, Ethylene glycol monomethacrylate, 4-02-00-01530, BRN 1071583, EINECS 212-782-2 (+11 more)
HEMA (CAS 868-77-9) is a cosmetic cosmetic ingredient functioning as Nail Sculpting. NOAEL 0.5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 868-77-9 →
Auto-generated CPSR Part A draft with source citations
Function
Nail Sculpting
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-hydroxyethyl 2-methylprop-2-enoate
InChIKey
WOBHKFSMXKNTIM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
CIR: SQ - IJT 24(Suppl 5):53-100, 2005
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
2 study endpoints found for HEMA. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
Excl markWarnCancerHealth haz
Hazard Statements
May be harmful if swallowed Causes skin and eye irritation May cause allergic skin reaction May be harmful if swallowed and enters airways
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. See Notes.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for HEMA across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Hazard Statements
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Nail products.
BRIN Brazil/India Cosmetics
India: Restricted
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1724
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritating to eyes and skin.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Thickening agent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for HEMA.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HEMA by CAS number or substance name.
Studies
2
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-propenoic acid, 2-methyl-, 2-hydroxyethyl ester
Ethylene glycol monomethacrylate
4-02-00-01530
BRN 1071583
EINECS 212-782-2
Ethylene glycol, monomethacrylate
Mhoromer
Monomer MG-1
Monomethacrylic ether of ethylene glycol
UNII-6E1I4IV47V
(hydroxyethyl)methacrylate
1,2-Ethanediol mono(2-methyl)-2-propenoate
2-Hydroxyethyl 2-methylacrylate
2-Hydroxyethylmethacrylate
Ethylene glycol methacrylate
beta-Hydroxyethyl methacrylate
Chemical Function
Film former
Regulatory Lists
Indirect additives food contact (10/2018)
Arts and crafts/Office supplies; Europe
air; Cons electronics mech appliances and machinery; detected; emissions; Europe
Europe; Personal care - nails
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1730239
Frequently Asked Questions
Is HEMA allowed in the EU?
HEMA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does HEMA do in cosmetics?
HEMA functions as: Nail Sculpting. It is classified as a cosmetic ingredient in our database. CAS number: 868-77-9.
What is the NOAEL for HEMA?
The NOAEL (No Observed Adverse Effect Level) for HEMA is =100 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is HEMA classified as hazardous under GHS?
HEMA carries a GHS signal word of "WARNING". Hazard statements: May be harmful if swallowed Causes skin and eye irritation May cause allergic skin reaction May be harmful if swallowed and enters airways. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is HEMA used outside cosmetics?
HEMA also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check HEMA compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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