Also known as: 2-propenoic acid, 2-methyl-, 2-hydroxyethyl ester, Ethylene glycol monomethacrylate, 4-02-00-01530, BRN 1071583, EINECS 212-782-2 (+12 more)
CAS 868-77-9
2-Hydroxyethyl methacrylate (CAS 868-77-9) is a chemical substance with GHS signal word Warning; key hazard signal: H315; H319; H317. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
View cosmetic safety profile for HEMA (2-Hydroxyethyl Methacrylate) →
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 | H315; H319; H317 | GHS07 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | May be harmful if swallowed Causes skin and eye irritation May cause allergic skin reaction May be harmful if swallowed and enters airways |
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. See Notes. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Arts and crafts/Office supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - nails | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =4.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 6E1I4IV47V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6E1I4IV47V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6E1I4IV47V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6E1I4IV47V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ~1030 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1863 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =532.285 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=2050 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=4100 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =150 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 14 of 14 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-hydroxyethyl methacrylate | 212-782-2 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
2-Hydroxyethyl methacrylate (CAS 868-77-9) is classified under EU CLP Annex VI as Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H315; H319; H317. Source: EU CLP Annex VI (ECHA).
2-Hydroxyethyl methacrylate has 14 NOAEL studies in the database. The lowest reported value is 4.9 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
2-Hydroxyethyl methacrylate appears on 4 regulatory/inventory lists including Indirect additives food contact (10/2018), Arts and crafts/Office supplies; Europe, air; Cons electronics mech appliances and machinery; detected; emissions; Europe, and 1 more. Source: EPA CPDat.
Yes, 2-Hydroxyethyl methacrylate is also indexed as a cosmetic ingredient under the name HEMA (2-Hydroxyethyl Methacrylate). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
2-Hydroxyethyl methacrylate also appears in cosmetics, pharmaceutical databases.