NOAEL Studies
Cosmetic Ingredient
HEMA NOAEL Studies
CAS: 868-77-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEC | ~1030 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c819e4b0a7c65d216af1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13815/7/8?documentUUID=5f11e66e-630d-4d79-b839-706ec192f83e; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819000_15819001:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d867218ff83ec03fa18543fce7de6c57 |
| ECHA | LOAEC | =1863 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15124/7/6/3?documentUUID=b5e326a0-699f-4d39-9f1e-2fabfdc6d07f; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829036_15829037:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4a3c4ff7e867f201bddf220624bf99b5 |
| ECHA | NOAEC | =532.285 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15124/7/6/3?documentUUID=b5e326a0-699f-4d39-9f1e-2fabfdc6d07f; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829036_15829037:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c1174ea426ffd2851a2e16a058d153ad |
| ECHA | NOAEC | >=2050 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c819e4b0a7c65d216af1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13815/7/8?documentUUID=5f11e66e-630d-4d79-b839-706ec192f83e; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15818998:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9a1cf324643d1750e33490b0d8762a76 |
| ECHA | NOAEC | >=4100 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c819e4b0a7c65d216af1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13815/7/8?documentUUID=5f11e66e-630d-4d79-b839-706ec192f83e; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15818999:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_918efd95547e47ab4ea1552dd461bdd8 |
| ECHA | NOAEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 49 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf3fe4b0a7c65d1cd166; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15124/7/6/2?documentUUID=b5e326a0-699f-4d39-9f1e-2fabfdc6d07f; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=clinical biochemistry|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ECHA IUCLID:15840772:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5d9a395748373c62203c5fae97dcccd2 |
| ECHA | NOAEL | =300 | mg/kg bw/day | Rat | oral | subchronic (developmental); 39 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf3fe4b0a7c65d1cd166; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15124/7/6/2?documentUUID=b5e326a0-699f-4d39-9f1e-2fabfdc6d07f; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15840773:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5b5bc7de5b61be26631bac8d3890c283 |
| ECHA | NOEL | =50 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba67c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15124/7/9/2?documentUUID=b5e326a0-699f-4d39-9f1e-2fabfdc6d07f; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=P0: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15855440:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_845ed454278b2738dc1bf6575c23ec64 |
| ECHA | NOEL | =150 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba67c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15124/7/9/2?documentUUID=b5e326a0-699f-4d39-9f1e-2fabfdc6d07f; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=P1: body weight and weight gain|P1: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15858095:M/F:P1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c907f4704573499a58d9f10e37747b94 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =4.9 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632696:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_33bd9d635134f9cb80ea2a0884ee6d48 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 6E1I4IV47V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6E1I4IV47V"} |
| openFDA substances | FDA UNII substance identifier | 6E1I4IV47V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6E1I4IV47V"} |
| openFDA substances | FDA UNII substance identifier | 6E1I4IV47V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6E1I4IV47V"} |
| openFDA substances | FDA UNII substance identifier | 6E1I4IV47V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6E1I4IV47V"} |