Is Heliotropine safe in cosmetics?
Heliotropine has a safety rating of "POOR" in our database. EU status: restricted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Heliotropine
Also known as: Benzaldehyde, 3,4-(methylenedioxy)-, 3,4-Bis(methylenedioxy)benzaldehyde, Dioxymethylene protocatechuic aldehyde, Dioxymethylene-protocatechuic aldehyde, EINECS 204-409-7 (+5 more)
INCI: HELIOTROPINE
Heliotropine (CAS 120-57-0) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with vanilla/almond aroma; fixative; masking agent. NOAEL 17 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 120-57-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Heliotropine is classified GHS Danger (H317, H301, H312, H330, H336, H351, H360, H370) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient with vanilla/almond aroma; fixative; masking agent
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1,3-benzodioxole-5-carbaldehyde
InChIKey
SATCULPHIDQDRE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted with no FDA restriction; FEMA GRAS; listed as fragrance ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Heliotropine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Heliotropine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | =300 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =390 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Heliotropine across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 112 | 0 | 2953 | 2953 | non-sensitizer |
| HMT | - | 0 | 3724.14 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| TH | banned | 0% | All cosmetic products |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Skin Eye Respiratory Irritation
A human skin irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
896
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PIPERONYL ALDEHYDE | 2001 | 0-2.5 mg/kg bw (1967) | No safety concern at current levels of intake when used as a flavouring agent. The 1967 ADI of 0-2.5 mg/kg bw was maintained at the fifty-seventh meeting (2001). | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Heliotropine.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Heliotropine by CAS number or substance name.
Studies
4
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
Benzaldehyde, 3,4-(methylenedioxy)-
3,4-Bis(methylenedioxy)benzaldehyde
Dioxymethylene protocatechuic aldehyde
Dioxymethylene-protocatechuic aldehyde
EINECS 204-409-7
FEMA No. 2911
3,4-Methylene-dihydroxybenzaldehyde
UNII-KE109YAK00
3,4-methylenedioxybenzaldehyde
piperonyl aldehyde
Chemical Function
Fragrance
Deodorizer
Softener and conditioner
Regulatory Lists
active_ingredient; Europe; Pesticides
Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PIPERONAL
ChEMBL ID
CHEMBL271663
Frequently Asked Questions
Is Heliotropine allowed in the EU?
Heliotropine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Heliotropine do in cosmetics?
Heliotropine functions as: Fragrance ingredient with vanilla/almond aroma; fixative; masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 120-57-0.
What is the NOAEL for Heliotropine?
The NOAEL (No Observed Adverse Effect Level) for Heliotropine is 100 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Is Heliotropine used outside cosmetics?
Heliotropine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Heliotropine have different safety status in cosmetics vs industrial chemicals?
Heliotropine is classified GHS Danger (H317, H301, H312, H330, H336, H351, H360, H370) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Heliotropine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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