What is the NOAEL for Piperonal?
Piperonal has 18 NOAEL studies in the database. The lowest reported value is 2.5 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Piperonal
Also known as: Benzaldehyde, 3,4-(methylenedioxy)-, 3,4-Bis(methylenedioxy)benzaldehyde, Dioxymethylene protocatechuic aldehyde, Dioxymethylene-protocatechuic aldehyde, EINECS 204-409-7 (+6 more)
CAS 120-57-0
Piperonal (CAS 120-57-0) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Piperonal is classified GHS Danger (H317, H301, H312, H330, H336, H351, H360, H370) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Piperonal
CAS Number
120-57-0
DTXSID
DTXSID7025924
Molecular Formula
C8H6O3
InChI Key
SATCULPHIDQDRE-UHFFFAOYSA-N
Monoisotopic Mass
150.031694
Synonyms
Benzaldehyde, 3,4-(methylenedioxy)-3,4-Bis(methylenedioxy)benzaldehydeDioxymethylene protocatechuic aldehydeDioxymethylene-protocatechuic aldehydeEINECS 204-409-7FEMA No. 29113,4-Methylene-dihydroxybenzaldehydeUNII-KE109YAK003,4-methylenedioxybenzaldehydeheliotropinepiperonyl aldehyde
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=2.5 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =5.29 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| KE109YAK00 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KE109YAK00 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KE109YAK00 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KE109YAK00 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3724 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =250 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =250 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =390 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 18 of 18 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Piperonal | 204-409-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PIPERONAL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 0-2.5 mg/kg bw (1967) mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Piperonal?
Piperonal appears on 7 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe, IFRA Transparency, and 4 more. Source: EPA CPDat.
Is Piperonal used in cosmetics?
Yes, Piperonal is also indexed as a cosmetic ingredient under the name Heliotropine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Piperonal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Piperonal have different safety status in cosmetics vs industrial chemicals?
Piperonal is classified GHS Danger (H317, H301, H312, H330, H336, H351, H360, H370) in the chemicals database but is restricted in EU cosmetics.
Is Piperonal used outside industrial chemicals?
Piperonal also appears in cosmetics, pharmaceutical, food safety, cannabis databases.