Is Glucosamine HCl safe in cosmetics?
Glucosamine HCl has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Glucosamine HCl
Also known as: 2-Amino-D-glucose, EINECS 200-638-1, Glucopyranose, 2-amino-2-deoxy-, hydrochloride, D-, D-Glucosamine monohydrochloride, UNII-750W5330FY
INCI: GLUCOSAMINE HCL
Glucosamine HCl (CAS 66-84-2) is a cosmetic cosmetic ingredient functioning as pH Adjuster, Skin Conditioning, Anti-Hyperpigmentation. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 66-84-2 →
Auto-generated CPSR Part A draft with source citations
Function
pH Adjuster, Skin Conditioning, Anti-Hyperpigmentation
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2R,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride
InChIKey
CBOJBBMQJBVCMW-BTVCFUMJSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel (June 2022) concluded safe in present practices of use and concentration when formulated to be non-irritating.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glucosamine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "hydration-plumping, brightening", "mechanism_of_action": "Humectant, water binding, barrier support", "target_skin_layer": "stratum corneum, epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "…
anti_pollution
{"cas_number": "66-84-2", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibition…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Flavouring and nutrient
Softener and conditioner
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Glucosamine HCl.
Known Synonyms
2-Amino-D-glucose
EINECS 200-638-1
Glucopyranose, 2-amino-2-deoxy-, hydrochloride, D-
D-Glucosamine monohydrochloride
UNII-750W5330FY
Chemical Function
Anti-static agent
Softener and conditioner
pH regulating agent
Flavouring and nutrient
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
81
Frequently Asked Questions
Is Glucosamine HCl allowed in the EU?
Glucosamine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glucosamine HCl do in cosmetics?
Glucosamine HCl functions as: pH Adjuster, Skin Conditioning, Anti-Hyperpigmentation. It is classified as a cosmetic ingredient in our database. CAS number: 66-84-2.
Is Glucosamine HCl used outside cosmetics?
Glucosamine HCl also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Glucosamine HCl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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