Is Pyridoxal safe in cosmetics?
Pyridoxal has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Pyridoxal
Also known as: 5-21-13-00044, BRN 0383768, EINECS 200-630-8, 3-Hydroxy-5-hydroxymethyl-2-methyl-4-pyridincarbaldehyd, UNII-3THM379K8A (+3 more)
INCI: PYRIDOXAL
Pyridoxal (CAS 66-72-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent, antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 66-72-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent, antioxidant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde
InChIKey
RADKZDMFGJYCBB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no FDA restrictions. Vitamin B6 aldehyde form; CIR has not conducted a dedicated review, but pyridoxine derivatives are widely used
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pyridoxal.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Pyridoxal.
Known Synonyms
5-21-13-00044
BRN 0383768
EINECS 200-630-8
3-Hydroxy-5-hydroxymethyl-2-methyl-4-pyridincarbaldehyd
UNII-3THM379K8A
3-hydroxy-2-methyl-5-methylol-isonicotinaldehyde
3-hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carbaldehyde
3-hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxaldehyde
Regulatory Lists
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PYRIDOXAL
ChEMBL ID
CHEMBL102970
Max Phase
3
Frequently Asked Questions
Is Pyridoxal allowed in the EU?
Pyridoxal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pyridoxal do in cosmetics?
Pyridoxal functions as: Skin conditioning agent, antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 66-72-8.
Is Pyridoxal used outside cosmetics?
Pyridoxal also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Pyridoxal compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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